PMID- 26256868
OWN - NLM
STAT- MEDLINE
DCOM- 20151106
LR  - 20211203
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 56
IP  - 6
DP  - 2015 Jun
TI  - [Roles of mTOR signalings in hematopoiesis and leukemogenesis].
PG  - 601-5
LID - 10.11406/rinketsu.56.601 [doi]
AB  - Mechanistic/mammalian target protein of rapamycin (mTOR) is an evolutionarily 
      conserved kinase that plays a critical role in sensing and responding to growth 
      factors, cytokines and nutrients, including amino acids and glucose. Although 
      mTOR was originally discovered as a target protein of rapamycin, the inhibitory 
      effects of rapamycin on mTORC1 substrates are complex. Recent studies using 
      genetic approaches have clearly demonstrated the physiological roles of mTOR 
      complexes in regulating the maintenance of hematopoietic and leukemia stem cells. 
      Advances in understanding of how mTOR signaling is involved in mechanisms of 
      normal hematopoiesis and leukemogenesis may lead to novel therapeutic approaches 
      that can successfully eradicate leukemia.
FAU - Hirao, Atsushi
AU  - Hirao A
AD  - Division of Molecular Genetics, Cancer Research Institute, Kanazawa University.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Cell Transformation, Neoplastic/*metabolism
MH  - *Hematopoiesis
MH  - Humans
MH  - Leukemia/*metabolism/*pathology
MH  - *Signal Transduction
MH  - Stem Cells/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2015/08/11 06:00
MHDA- 2015/11/07 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2015/11/07 06:00 [medline]
AID - 10.11406/rinketsu.56.601 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2015 Jun;56(6):601-5. doi: 10.11406/rinketsu.56.601.