PMID- 26257137
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20161230
IS  - 1939-3806 (Electronic)
IS  - 1939-3806 (Linking)
VI  - 9
IP  - 1
DP  - 2016 Jan
TI  - Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates 
      Autism Related Behaviors in BTBR Mice.
PG  - 17-32
LID - 10.1002/aur.1530 [doi]
AB  - Autism spectrum disorders (ASD) are characterized by social communication 
      deficits, cognitive rigidity, and repetitive stereotyped behaviors. Mesenchymal 
      stem cells (MSC) have a paracrine regenerative effect, and were speculated to be 
      a potential therapy for ASD. The BTBR inbred mouse strain is a commonly used 
      model of ASD as it demonstrates robust behavioral deficits consistent with the 
      diagnostic criteria for ASD. BTBR mice also exhibit decreased brain-derived 
      neurotrophic factor (BDNF) signaling and reduced hippocampal neurogenesis. In the 
      current study, we evaluated the behavioral and molecular effects of 
      intracerebroventricular MSC transplantation in BTBR mice. Transplantation of MSC 
      resulted in a reduction of stereotypical behaviors, a decrease in cognitive 
      rigidity and an improvement in social behavior. Tissue analysis revealed elevated 
      BDNF protein levels in the hippocampus accompanied by increased hippocampal 
      neurogenesis in the MSC-transplanted mice compared with sham treated mice. This 
      might indicate a possible mechanism underpinning the behavioral improvement. Our 
      study suggests a novel therapeutic approach which may be translatable to ASD 
      patients in the future.
CI  - (c) 2015 International Society for Autism Research, Wiley Periodicals, Inc.
FAU - Segal-Gavish, Hadar
AU  - Segal-Gavish H
AD  - Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv 
      University, Tel- Aviv, Israel.
FAU - Karvat, Golan
AU  - Karvat G
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Barak, Noy
AU  - Barak N
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Barzilay, Ran
AU  - Barzilay R
AD  - Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv 
      University, Tel- Aviv, Israel.
AD  - Geha Mental Health Center, Petah Tikva, Israel.
FAU - Ganz, Javier
AU  - Ganz J
AD  - Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv 
      University, Tel- Aviv, Israel.
FAU - Edry, Liat
AU  - Edry L
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Aharony, Israel
AU  - Aharony I
AD  - Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv 
      University, Tel- Aviv, Israel.
FAU - Offen, Daniel
AU  - Offen D
AD  - Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv 
      University, Tel- Aviv, Israel.
FAU - Kimchi, Tali
AU  - Kimchi T
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150810
PL  - United States
TA  - Autism Res
JT  - Autism research : official journal of the International Society for Autism 
      Research
JID - 101461858
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Autistic Disorder/*physiopathology/*therapy
MH  - Behavior, Animal
MH  - Disease Models, Animal
MH  - Hippocampus/metabolism
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neurogenesis/*physiology
MH  - Proteins/metabolism
MH  - *Social Behavior
MH  - Stereotyped Behavior/*physiology
OTO - NOTNLM
OT  - BDNF
OT  - BTBR
OT  - MSC
OT  - animal model
OT  - neurogenesis
EDAT- 2015/08/11 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/08/11 06:00
PHST- 2014/12/14 00:00 [received]
PHST- 2015/07/17 00:00 [accepted]
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 10.1002/aur.1530 [doi]
PST - ppublish
SO  - Autism Res. 2016 Jan;9(1):17-32. doi: 10.1002/aur.1530. Epub 2015 Aug 10.