PMID- 26257153
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20161231
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 48
IP  - 4
DP  - 2016 May
TI  - Characterisation of dendritic cell subsets in chronically inflamed human 
      epididymis.
PG  - 431-40
LID - 10.1111/and.12463 [doi]
AB  - Infection and inflammation of the genital tract are thought to be a primary 
      aetiological factor of male infertility. Chronic epididymitis appears to be more 
      important than prostatitis or seminal vesiculitis due to the direct interaction 
      between sperm cells and epididymal epithelium. Dendritic cells (DCs) are a 
      heterogeneous population of antigen-presenting cells that play a crucial role in 
      the regulation of the immune response and immunological tolerance. The aim of 
      this study was to investigate the expression and characteristic of different DC 
      subsets in chronic inflammation of human epididymis and controls. Our study 
      demonstrated that normal human epididymis contained only immature CD1a(+) DCs, 
      CD11c(+) myeloid DCs (mDCs) and CD209(+) DCs whereas CD123(+) plasmacytoid DCs 
      and CD83(+) mature DCs were virtually absent. The number of both CD11c(+) 
      IL-23(+) mDCs and CD123(+) pDCs were significantly elevated in inflamed 
      epididymis; meanwhile the mDC populations of CD1a(+), CD209(+) immature DCs and 
      CD83(+) mature DCs also increased in inflamed group. Moreover, Th17 (CD4(+) 
      IL-17(+)) cells were predominantly distributed under chronic inflammation of 
      human epididymis. Taken together these results suggest that epididymal DCs might 
      play a pivotal role in the development of chronic epididymitis and induce an 
      increased recruitment of Th17 cells under inflammatory conditions.
CI  - (c) 2015 Blackwell Verlag GmbH.
FAU - Duan, Y-G
AU  - Duan YG
AD  - Centre of Reproductive Medicine and Andrology, The First Affiliated Hospital of 
      Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
AD  - Shenzhen PKU-HKUST Medical Center, Peking University Shenzhen Hospital, Shenzhen, 
      China.
FAU - Wang, P
AU  - Wang P
AD  - Department of Urology, Daping Hospital, Institute of Surgery Research, Third 
      Military Medical University, Chongqing, China.
FAU - Zheng, W
AU  - Zheng W
AD  - Shenzhen PKU-HKUST Medical Center, Peking University Shenzhen Hospital, Shenzhen, 
      China.
FAU - Zhang, Q
AU  - Zhang Q
AD  - Centre of Reproductive Medicine and Andrology, The First Affiliated Hospital of 
      Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
FAU - Huang, W
AU  - Huang W
AD  - Centre of Reproductive Medicine and Andrology, The First Affiliated Hospital of 
      Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
FAU - Jin, F
AU  - Jin F
AD  - Department of Urology, Daping Hospital, Institute of Surgery Research, Third 
      Military Medical University, Chongqing, China.
FAU - Cai, Z
AU  - Cai Z
AD  - Centre of Reproductive Medicine and Andrology, The First Affiliated Hospital of 
      Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
AD  - Shenzhen PKU-HKUST Medical Center, Peking University Shenzhen Hospital, Shenzhen, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150809
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Antigens, CD)
RN  - 0 (IL17A protein, human)
RN  - 0 (IL23A protein, human)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-23 Subunit p19)
SB  - IM
MH  - Antigens, CD/*metabolism
MH  - Chronic Disease
MH  - Dendritic Cells/*metabolism
MH  - Epididymis/*cytology/immunology/pathology
MH  - Epididymitis/*immunology/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-17/metabolism
MH  - Interleukin-23 Subunit p19/metabolism
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Spermatozoa/immunology
MH  - Th17 Cells/*metabolism
OTO - NOTNLM
OT  - Autoimmune response
OT  - chronic epididymitis
OT  - dendritic cells
OT  - epididymal immunopathology
OT  - male infertility
EDAT- 2015/08/11 06:00
MHDA- 2016/12/31 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/06/16 00:00 [accepted]
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.1111/and.12463 [doi]
PST - ppublish
SO  - Andrologia. 2016 May;48(4):431-40. doi: 10.1111/and.12463. Epub 2015 Aug 9.