PMID- 26257358
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20150810
IS  - 1001-0742 (Print)
IS  - 1001-0742 (Linking)
VI  - 34
DP  - 2015 Aug 1
TI  - Disruption of iron homeostasis and resultant health effects upon exposure to 
      various environmental pollutants: A critical review.
PG  - 155-64
LID - S1001-0742(15)00175-8 [pii]
LID - 10.1016/j.jes.2015.04.004 [doi]
AB  - Environmental pollution has become one of the greatest problems in the world, and 
      the concerns about environmental pollutants released by human activities from 
      agriculture and industrial production have been continuously increasing. Although 
      intense efforts have been made to understand the health effects of environmental 
      pollutants, most studies have only focused on direct toxic effects and failed to 
      simultaneously evaluate the long-term adaptive, compensatory and secondary 
      impacts on health. Burgeoning evidence suggests that environmental pollutants may 
      directly or indirectly give rise to disordered element homeostasis, such as for 
      iron. It is crucially important to maintain concerted cellular and systemic iron 
      metabolism. Otherwise, disordered iron metabolism would lead to cytotoxicity and 
      increased risk for various diseases, including cancers. Thus, study on the 
      effects of environmental pollutants upon iron homeostasis is urgently needed. In 
      this review, we recapitulate the available findings on the direct or indirect 
      impacts of environmental pollutants, including persistent organic pollutants 
      (POPs), heavy metals and pesticides, on iron homeostasis and associated adverse 
      health problems. In view of the unanswered questions, more efforts are warranted 
      to investigate the disruptive effects of environmental pollutants on iron 
      homeostasis and consequent toxicities.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Guo, Wenli
AU  - Guo W
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China. Electronic address: biogwl@126.com.
FAU - Zhang, Jie
AU  - Zhang J
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China. Electronic address: sdzhangjie1989@163.com.
FAU - Li, Wenjun
AU  - Li W
AD  - School of Stomatology, Wuhan University, Wuhan 430072, China.
FAU - Xu, Ming
AU  - Xu M
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China. Electronic address: mingxu@rcees.ac.cn.
FAU - Liu, Sijin
AU  - Liu S
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China. Electronic address: sjliu@rcees.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150525
PL  - Netherlands
TA  - J Environ Sci (China)
JT  - Journal of environmental sciences (China)
JID - 100967627
RN  - 0 (Environmental Pollutants)
RN  - 0 (Metals, Heavy)
RN  - 0 (Pesticides)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*toxicity
MH  - Homeostasis/*drug effects
MH  - Humans
MH  - Iron/*metabolism
MH  - Metals, Heavy/*toxicity
MH  - Pesticides/*toxicity
OTO - NOTNLM
OT  - Ferroportin
OT  - Heavy metals
OT  - Hepcidin
OT  - Iron diseases
OT  - Iron homeostasis
OT  - Organophosphate pesticides
OT  - Persistent organic pollutants
EDAT- 2015/08/11 06:00
MHDA- 2016/08/10 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/04/07 00:00 [received]
PHST- 2015/04/19 00:00 [revised]
PHST- 2015/04/20 00:00 [accepted]
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
AID - S1001-0742(15)00175-8 [pii]
AID - 10.1016/j.jes.2015.04.004 [doi]
PST - ppublish
SO  - J Environ Sci (China). 2015 Aug 1;34:155-64. doi: 10.1016/j.jes.2015.04.004. Epub 
      2015 May 25.