PMID- 26257368
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20150810
IS  - 1001-0742 (Print)
IS  - 1001-0742 (Linking)
VI  - 34
DP  - 2015 Aug 1
TI  - New insights into disruption of iron homeostasis by environmental pollutants.
PG  - 256-8
LID - S1001-0742(15)00230-2 [pii]
LID - 10.1016/j.jes.2015.06.001 [doi]
AB  - Among the numerous health conditions environmental pollutants can cause, chronic 
      exposure to pollutants including persistent organic pollutants (POPs) and heavy 
      metals has been shown to disturb a specific biological homeostatic process, the 
      iron metabolism in human body. Disorders of iron metabolism are among the common 
      diseases of humans and encompass a broad spectrum of diseases with different 
      clinical manifestations, ranging from anemia to iron overload, and possibly to 
      neurodegenerative diseases and cancer. Hepcidin-ferroportin (FPN) signaling is 
      one of the key mechanisms responsible for iron supply, utilization, recycling, 
      and storage, and recent studies demonstrated that exposure to environmental 
      pollutants including POPs and heavy metals could lead to disruption of the 
      hepcidin-FPN axis along with disordered systemic iron homeostasis and diseases. 
      This article introduces and highlights the accompanying review article by Drs. Xu 
      and Liu in this journal, which elaborates in detail the adverse effects of 
      environmental pollutants on iron metabolism, and the mechanisms responsible for 
      these toxicological outcomes. It also points out the knowledge gaps still 
      existing in this subject matter. Research that will fill these gaps will improve 
      our understanding of the issue and provide useful information to prevent or treat 
      diseases induced by environmental pollutants.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Wang, Xiang
AU  - Wang X
AD  - Department of Medicine, Division of NanoMedicine, University of California, Los 
      Angeles, CA 90095, USA; California NanoSystems Institute, University of 
      California, Los Angeles, CA 90095, USA.
FAU - Xia, Tian
AU  - Xia T
AD  - Department of Medicine, Division of NanoMedicine, University of California, Los 
      Angeles, CA 90095, USA; California NanoSystems Institute, University of 
      California, Los Angeles, CA 90095, USA. Electronic address: txia@ucla.edu.
LA  - eng
PT  - Journal Article
DEP - 20150630
PL  - Netherlands
TA  - J Environ Sci (China)
JT  - Journal of environmental sciences (China)
JID - 100967627
RN  - 0 (Environmental Pollutants)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*toxicity
MH  - Homeostasis/*drug effects
MH  - Humans
MH  - Iron/*metabolism
OTO - NOTNLM
OT  - Environmental pollution
OT  - Ferroportin
OT  - Heavy metals
OT  - Hepcidin
OT  - Iron homeostasis
OT  - Persistent organic pollutants
EDAT- 2015/08/11 06:00
MHDA- 2016/08/10 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
AID - S1001-0742(15)00230-2 [pii]
AID - 10.1016/j.jes.2015.06.001 [doi]
PST - ppublish
SO  - J Environ Sci (China). 2015 Aug 1;34:256-8. doi: 10.1016/j.jes.2015.06.001. Epub 
      2015 Jun 30.