PMID- 26257380
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 81
DP  - 2015 Nov
TI  - In vitro release and biological activities of Carum copticum essential oil (CEO) 
      loaded chitosan nanoparticles.
PG  - 283-90
LID - S0141-8130(15)00545-0 [pii]
LID - 10.1016/j.ijbiomac.2015.08.010 [doi]
AB  - In recent years, the unparalleled and functional properties of essential oils 
      have been extensively reported, but the sensitivity of essential oils to 
      environmental factors and their poor aqueous solubility have limited their 
      applications in industries. Hence, we encapsulated CEO in chitosan nanoparticles 
      by an emulsion-ionic gelation with pantasodium tripolyphosphate (TPP) and sodium 
      hexametaphosphte (HMP), separately, as crosslinkers. The nanoparticles were 
      analyzed by Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible 
      spectroscopy (UV-vis), differential scanning calorimetry (DSC), scanning electron 
      microscope (SEM) and dynamic light scattering (DLS). The encapsulation efficiency 
      (EE) and loading capacity (LC) of CEO in chitosan nanoparticles increased with 
      the increase of initial CEO amount. The nanoparticles displayed an average size 
      of 30-80nm with a spherical shape and regular distribution. In vitro release 
      profiles exhibited an initial burst release and followed by a sustained CEO 
      release at different pH conditions. The amount of CEO release from chitosan 
      nanoparticles was higher in acidic pH to basic or neutral pH, respectively. The 
      biological properties of CEO, before and after the encapsulation process were 
      evaluated by 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and agar disk diffusion 
      method, respectively. The results indicated the encapsulation of CEO in chitosan 
      nanoparticles could be protected the quality.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Esmaeili, Akbar
AU  - Esmaeili A
AD  - Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, 
      PO Box 19585/936, Tehran, Iran. Electronic address: akbaresmaeili@yahoo.com.
FAU - Asgari, Azadeh
AU  - Asgari A
AD  - Department of Phytochemistry and Essential oils Technology, Faculty of 
      Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad 
      University, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150807
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Drug Carriers)
RN  - 0 (Oils, Volatile)
RN  - 0 (Phenols)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Anti-Infective Agents/chemistry/isolation & purification/pharmacology
MH  - Antioxidants/chemistry/isolation & purification/pharmacology
MH  - Calorimetry, Differential Scanning
MH  - Carum/*chemistry
MH  - Chemistry, Pharmaceutical
MH  - Chitosan/*chemistry
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Microbial Sensitivity Tests
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Oils, Volatile/*chemistry/isolation & purification/*pharmacology
MH  - Particle Size
MH  - Phenols/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Thermodynamics
OTO - NOTNLM
OT  - Biological activity
OT  - Carum copticum
OT  - Chitosan nanoparticles
OT  - Essential oil
EDAT- 2015/08/11 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/06/16 00:00 [received]
PHST- 2015/07/25 00:00 [revised]
PHST- 2015/08/04 00:00 [accepted]
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - S0141-8130(15)00545-0 [pii]
AID - 10.1016/j.ijbiomac.2015.08.010 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2015 Nov;81:283-90. doi: 10.1016/j.ijbiomac.2015.08.010. 
      Epub 2015 Aug 7.