PMID- 26258539
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 8
DP  - 2015
TI  - Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease 
      in a Chinese Han population.
PG  - e0135425
LID - 10.1371/journal.pone.0135425 [doi]
LID - e0135425
AB  - BACKGROUND: Accumulating evidence has demonstrated that the 
      glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a part of Lewy body 
      inclusions and involves the pathogenesis of Parkinson's disease (PD). However, it 
      remains unknown whether or not genetic variation at the GAPDH locus contributes 
      to the risk for PD. METHODS: A total of 302 sporadic PD patients and 377 control 
      subjects were recruited in our study for assessing two single nucleotide 
      polymorphisms (rs3741918 and rs1060619) in the GAPDH gene. Both allelic 
      association and additive models were used to analyze association between GAPDH 
      variants and risk for PD. RESULTS: Both polymorphisms were significantly 
      associated with risk for PD after correction by Bonferroni multiple testing. The 
      minor allele of rs3741918 was associated with decreased risk of sporadic PD 
      (allelic contrast, OR = 0.74, 95% CI: 0.59-0.93, corrected P = 0.028; additive 
      model, OR = 0.73, 95% CI: 0.58-0.92, corrected P = 0.018). While for the 
      rs1060619 locus, the minor allele conferred increased risk for PD (allelic 
      contrast, OR = 1.41, 95% CI: 1.14-1.75, corrected P = 0.007; additive model, OR = 
      1.43, 95% CI: 1.15-1.79, corrected P = 0.002). CONCLUSION: Our study indicates 
      that GAPDH variants confer susceptibility to sporadic PD in a Chinese Han 
      population, which is consistent with the role of GAPDH protein in neuronal 
      apoptosis. To our knowledge, this is the first study of genetic association 
      between GAPDH locus and risk for PD in the Chinese population.
FAU - Liu, Ling
AU  - Liu L
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Xiong, Nian
AU  - Xiong N
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Zhang, Ping
AU  - Zhang P
AD  - Department of Neurology, the Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, China.
FAU - Chen, Chunnuan
AU  - Chen C
AD  - Department of Neurology, the Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, Fujian, China.
FAU - Huang, Jinsha
AU  - Huang J
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Zhang, Guoxin
AU  - Zhang G
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Xu, Xiaoyun
AU  - Xu X
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Shen, Yan
AU  - Shen Y
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Lin, Zhicheng
AU  - Lin Z
AD  - Department of Psychiatry and Harvard NeuroDiscovery Center, Harvard Medical 
      School and Laboratory of Psychiatric Neurogenomics, Division of Alcohol and Drug 
      Abuse, McLean Hospital, Belmont, MA, United States of America.
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150810
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/*genetics
MH  - Humans
MH  - Lewy Bodies/chemistry/enzymology
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - Parkinson Disease/diagnosis/*genetics/pathology
MH  - *Polymorphism, Single Nucleotide
PMC - PMC4530932
COIS- Competing Interests: The authors have read the journal's policy and the authors 
      of this manuscript have the following competing interests: Zhicheng Lin is an 
      Academic Editor for PLOS ONE. This does not alter the authors' adherence to all 
      the PLOS ONE policies on sharing data and materials. Other authors have declared 
      that no competing interests exist.
EDAT- 2015/08/11 06:00
MHDA- 2016/05/11 06:00
PMCR- 2015/08/10
CRDT- 2015/08/11 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/07/21 00:00 [accepted]
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
PHST- 2015/08/10 00:00 [pmc-release]
AID - PONE-D-15-09244 [pii]
AID - 10.1371/journal.pone.0135425 [doi]
PST - epublish
SO  - PLoS One. 2015 Aug 10;10(8):e0135425. doi: 10.1371/journal.pone.0135425. 
      eCollection 2015.