PMID- 26258691
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20220317
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 19
IP  - 1
DP  - 2016 Jan
TI  - Adult Behcet's disease in Iran: analysis of 6075 patients.
PG  - 95-103
LID - 10.1111/1756-185X.12691 [doi]
AB  - INTRODUCTION: This is an analysis of adult Behcet's disease (BD) in Iran, from 
      the Iran Registry of 7187 BD patients, gathered from 1975 to 2014, among which 
      6075 were adults (84.5%). PATIENTS: Patients were seen by a multidisciplinary 
      team of experts. The diagnosis was by expert opinion, not by any specific 
      classification/diagnosis criteria. However, 96.8% of them were classified by the 
      International Criteria for Behcet's Disease (ICBD). Adult BDs were patients who 
      had their first manifestation at the age of 16 or later. RESULTS: Males 
      constituted 56% (male/female ratio 1.3/1). The mean age at onset was 28.3 +/- 8.7, 
      mean duration 10.8 +/- 8.2, and mean follow-up 5.0 +/- 6.3. Oral aphthosis was seen 
      in 97.5%, genital aphthosis 65.7%, skin manifestations 64.6% (pseudofolliculitis 
      53.2%, erythema nodosum 23.9%), ocular manifestations 58.1% (anterior uveitis 
      41.1%, posterior uveitis 45%, retinal vasculitis 33.6%, cataract 24.4%), joint 
      manifestations 39.4% (arthralgia 18.9%, monoarthritis 9.1%, oligoarthritis 17.8%, 
      ankyloing spondylitis 2%), gastrointestinal manifestations 7% (gastroduodenitis 
      2.3%, peptic ulcer 1.2%, diarrhea 2.1%, rectorrhagia 1.0%, abdominal pain-nausea 
      1.8%), neurological manifestations 10.6% (central 3.7%, peripheral 0.3%, headache 
      7.6%), vessel involvement (large vessel 1.7% with large vein thrombosis 1.1% and 
      arterial involvement 0.7%, phlebitis 6.6%, superficial phlebitis 2.3%), 
      epididymitis 4.6%, pulmonary manifestations 1% and cardiac manifestations 0.6%. 
      Positive pathergy test was seen in 52.3%, human leukocyte antigen (HLA)-B5 in 
      54%, HLA-B51 in 48.9%, and high erythrocyte sedimentation rate in 52.8% of 
      patients. By International Study Group (ISG) criteria 77.9% were classified, 
      compared to ICBD revised criteria with 96.9%. The specificity of ISG was 99.2% 
      and ICBD 97.2%. CONCLUSION: Results are near the nationwide surveys from Japan, 
      China, Korea and Germany.
CI  - (c) 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing 
      Asia Pty Ltd.
FAU - Davatchi, Fereydoun
AU  - Davatchi F
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Chams-Davatchi, Cheyda
AU  - Chams-Davatchi C
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Shams, Hormoz
AU  - Shams H
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Nadji, Abdolhadi
AU  - Nadji A
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Faezi, Tahereh
AU  - Faezi T
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Akhlaghi, Massoomeh
AU  - Akhlaghi M
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Sadeghi Abdollahi, Bahar
AU  - Sadeghi Abdollahi B
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Ashofteh, Farimah
AU  - Ashofteh F
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Ghodsi, Zahra
AU  - Ghodsi Z
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Mohtasham, Negin
AU  - Mohtasham N
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
FAU - Shahram, Farhad
AU  - Shahram F
AD  - Behcet's Disease Unit, Rheumatology Research Center, Tehran University of Medical 
      Sciences, Shariati Hospital, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150810
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Behcet Syndrome/diagnosis/*epidemiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Registries
MH  - Risk Factors
MH  - Sex Factors
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Behcet's disease
EDAT- 2015/08/11 06:00
MHDA- 2017/01/11 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/08/11 06:00 [entrez]
PHST- 2015/08/11 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - 10.1111/1756-185X.12691 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2016 Jan;19(1):95-103. doi: 10.1111/1756-185X.12691. Epub 2015 
      Aug 10.