PMID- 26260748
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20151002
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 84
DP  - 2015 Oct
TI  - Genistein reduces the noxious effects of in utero bisphenol A exposure on the rat 
      prostate gland at weaning and in adulthood.
PG  - 64-73
LID - S0278-6915(15)30019-3 [pii]
LID - 10.1016/j.fct.2015.07.011 [doi]
AB  - Bisphenol A (BPA) is one hormonally active chemical with potential deleterious 
      effects on reproductive organs, including breast and prostate. In contrast, 
      genistein (GEN) is the major phytoestrogen of soy that presents potential 
      protective effects against hormone-dependent cancers, including that of the 
      prostate. Thus, pregnant Sprague-Dawley rats were treated with BPA at 25 or 250 
      mug/kg/day by gavage from gestational day (GD) 10-21 with or without dietary GEN 
      at 250 mg/kg/chow ( approximately 5.5 mg/kg/day). Then, male offspring from different litters 
      were euthanized on post-natal day (PND) 21 and 180. At PND21, BPA 25 exposure 
      induced early prostatic changes while dietary GEN attenuated some deleterious 
      actions this xenoestrogen on epithelial cell proliferation levels, androgen 
      receptor expression and prostatic architecture in male offspring. At PND180, a 
      significant increase in incidence of prostatic multifocal inflammation/reactive 
      hyperplasia and atypical hyperplasia were observed in male offspring from dams 
      that received BPA 25. On the other hand, maternal GEN feeding attenuated some the 
      adverse effects of BPA 25 on prostate disease at late-in-life. This way, the 
      present findings point to preventive action of dietary GEN on deleterious effects 
      of gestational BPA exposure in both early and late prostate development in 
      offspring F1.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Bernardo, Bruna Dias
AU  - Bernardo BD
AD  - UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, 
      Botucatu, SP, 18618-970, Brazil.
FAU - Brandt, Joyce Zalotti
AU  - Brandt JZ
AD  - UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of 
      Morphology, Botucatu, SP, 18618-970, Brazil.
FAU - Grassi, Tony Fernando
AU  - Grassi TF
AD  - UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, 
      Botucatu, SP, 18618-970, Brazil.
FAU - Silveira, Livia Teresa R
AU  - Silveira LT
AD  - UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of 
      Morphology, Botucatu, SP, 18618-970, Brazil.
FAU - Scarano, Wellerson Rodrigo
AU  - Scarano WR
AD  - UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of 
      Morphology, Botucatu, SP, 18618-970, Brazil.
FAU - Barbisan, Luis Fernando
AU  - Barbisan LF
AD  - UNESP - Univ. Estadual Paulista, Institute of Biosciences, Department of 
      Morphology, Botucatu, SP, 18618-970, Brazil. Electronic address: 
      barbisan@ibb.unesp.br.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150808
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 0 (Phytoestrogens)
RN  - 0 (Receptors, Androgen)
RN  - DH2M523P0H (Genistein)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/administration & dosage/antagonists & inhibitors/toxicity
MH  - Cell Proliferation/drug effects
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Estrogens, Non-Steroidal/administration & dosage/*antagonists & 
      inhibitors/toxicity
MH  - Female
MH  - Genistein/*therapeutic use
MH  - Male
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Phenols/administration & dosage/antagonists & inhibitors/toxicity
MH  - Phytoestrogens/*therapeutic use
MH  - Pregnancy
MH  - Prenatal Exposure Delayed 
      Effects/metabolism/pathology/physiopathology/*prevention & control
MH  - Prostate/*drug effects/metabolism/pathology
MH  - Prostatic Hyperplasia/chemically induced/metabolism/pathology/prevention & 
      control
MH  - Prostatic Neoplasms/chemically induced/metabolism/pathology/prevention & control
MH  - Rats, Sprague-Dawley
MH  - Receptors, Androgen/metabolism
MH  - Specific Pathogen-Free Organisms
MH  - Weaning
OTO - NOTNLM
OT  - Bisphenol A
OT  - Genistein
OT  - Gestation
OT  - Prevention
OT  - Prostate development
OT  - Prostatic lesions in adulthood
EDAT- 2015/08/12 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/08/12 06:00
PHST- 2015/03/09 00:00 [received]
PHST- 2015/05/07 00:00 [revised]
PHST- 2015/07/15 00:00 [accepted]
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - S0278-6915(15)30019-3 [pii]
AID - 10.1016/j.fct.2015.07.011 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2015 Oct;84:64-73. doi: 10.1016/j.fct.2015.07.011. Epub 2015 
      Aug 8.