PMID- 26261480
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 6
DP  - 2015
TI  - Immunohistochemical phenotype and molecular pathological characteristics of 
      metanephric adenoma.
PG  - 6031-6
AB  - To assess the clinicopathological, immunohistochemical and molecular features of 
      metanephric adenoma (MA). Clinicopathologic data were obtained for 5 cases of MA 
      with follow-up information. Specimens from these patients were stained by HE and 
      immunohistochemistry for the detection of WT1, vimentin, S-100 protein, CK7, 
      P504s, CD10 and renal cell carcinoma marker (RCC). Fluorescence in situ 
      hybridization (FISH) was performed on 4 tumors. The patients included 1 male and 
      4 females, aged from 30 to 49 (mean=39) years. Tumor diameters ranged from 3 to 
      5.5 cm. Histologically, the tumors had tubular, papillary, or glomeruloid 
      architectures, and were composed of cells with uniform and round nuclei, 
      inconspicuous nucleoli, and high ratio of nucleus to cytoplasm. Nuclear 
      polymorphism and mitotic figures were not observed. Immunohistochemically, they 
      expressed WT1 (5/5), vimentin (5/5), S-100 (4/5), CK7 (2/5), P504s (2/5), and 
      CD10 (1/5) and not RCC. FISH study was carried out on 4 metanephric adenoma 
      cases, and no abnormalities were observed in chromosomes 3, 7, 17, and P16 gene 
      of chromosomes 9. MA is an uncommon renal tumor. Its diagnosis depends on 
      morphological, immunohistochemical and molecular features.
FAU - Sun, Zhulei
AU  - Sun Z
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
FAU - Kan, Shihai
AU  - Kan S
AD  - Department of Human Anatomy, Binzhou Medical College Yantai, China.
FAU - Zhang, Leilei
AU  - Zhang L
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
FAU - Jing, Hong
AU  - Jing H
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
FAU - Huang, Gui
AU  - Huang G
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
FAU - Yu, Qichun
AU  - Yu Q
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
FAU - Wu, Jiang
AU  - Wu J
AD  - Department of Pathology, First Hospital of The Henan University of Huaihe River 
      Kaifeng, China.
LA  - eng
PT  - Journal Article
DEP - 20150601
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adenoma/*chemistry/genetics/pathology/surgery
MH  - Adult
MH  - Biomarkers, Tumor/*analysis/genetics
MH  - Female
MH  - Humans
MH  - *Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*chemistry/genetics/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Nephrectomy
MH  - Predictive Value of Tests
MH  - Tomography, X-Ray Computed
MH  - Tumor Burden
PMC - PMC4525814
OTO - NOTNLM
OT  - FISH
OT  - Metanephric adenoma
OT  - immunohistochemistry
OT  - molecular pathology
EDAT- 2015/08/12 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/06/01
CRDT- 2015/08/12 06:00
PHST- 2015/03/23 00:00 [received]
PHST- 2015/05/22 00:00 [accepted]
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Jun 1;8(6):6031-6. eCollection 2015.