PMID- 26261648
OWN - NLM
STAT- MEDLINE
DCOM- 20160520
LR  - 20221207
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 6
DP  - 2015
TI  - Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma 
      risk.
PG  - 7431-5
AB  - PURPOSE: We carried out this study to find out the relevance between rs2281388 
      T/C polymorphism of human leukocyte antigen (HLA) gene and hepatocellular 
      carcinoma (HCC) risk in Chinese Han population. METHODS: The method of polymerase 
      chain reaction (PCR) was applied to amplify the genomic DNA. Then the PCR 
      products were sequenced to test the HLA-DP gene rs2281388T/C polymorphism of the 
      case and control groups. Odds ratios (ORs) and 95% confidence interval (95% CIs) 
      were utilized to evaluate the potential correlation between rs2281388 variants 
      and HCC risk. RESULTS: We analyzed the rs2281388 polymorphism distribution among 
      the clinical pathological features. The results showed that there existed a 
      significant statistic correlation between rs2281388T/C polymorphism of HLA-DP 
      gene and HBsAg feature, and no significant correlation was found between 
      rs2281388 and other clinical features. Further analysis showed that the TT 
      genotype of rs2281388 was significantly correlated with HCC risk, and the same to 
      T allele, but there was no significant difference of CT genotype distribution in 
      case and control groups. CONCLUSION: TT genotype and T allele of HLA-DP gene 
      rs2281388 polymorphism may increase the risk of HCC.
FAU - Liu, Fangfeng
AU  - Liu F
AD  - Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to 
      Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
FAU - Wang, Jianlu
AU  - Wang J
AD  - Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiiated to 
      Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to 
      Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
FAU - Lu, Jun
AU  - Lu J
AD  - Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to 
      Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
FAU - Li, Hongguang
AU  - Li H
AD  - Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to 
      Shandong University 9677 Jingshi Road, Jinan 250021, Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20150601
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (HLA-DP Antigens)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - Carcinoma, Hepatocellular/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-DP Antigens/*genetics
MH  - Humans
MH  - Liver Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC4525982
OTO - NOTNLM
OT  - HLA-DP gene
OT  - hepatocellular carcinoma
OT  - single nucleotide polymorphism
EDAT- 2015/08/12 06:00
MHDA- 2016/05/21 06:00
PMCR- 2015/06/01
CRDT- 2015/08/12 06:00
PHST- 2015/01/20 00:00 [received]
PHST- 2015/03/20 00:00 [accepted]
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/05/21 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Jun 1;8(6):7431-5. eCollection 2015.