PMID- 26261666
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 6
DP  - 2015
TI  - Richter transformation with c-MYC overexpression: report of three cases.
PG  - 7540-6
AB  - Pathogenesis of Richter transformation (RT) or Richter syndrome (RS) of chronic 
      lymphocytic leukemia (CLL) is still largely unknown. Increasing evidences show 
      that c-MYC may play a role in the development of RS. Here we report three cases 
      of RS with overexpression of c-MYC. The first case was a 78-year-old male who 
      initially presented with CLL and then developed diffuse lymphadenopathy and 
      ascites shortly after. Ascites cytology showed a population of large lymphoid 
      cells positive for MYC (8q24) rearrangement by fluorescence in situ hybridization 
      (FISH) and overexpression of c-MYC by immunohistochemistry (IHC). The second case 
      was a 66-year-old male presented with rapidly enlarging lymph nodes and pleural 
      effusion after a long history of CLL. Biopsy showed large B-cells positive for 
      c-MYC overexpression and high Ki-67 proliferation index (80-90%). The third case 
      was a 62-year-old female with CLL who presented for lobectomy for lung 
      adenocarcinoma. Interestingly, along with the carcinoma, large B-cell lymphoma 
      was incidentally found which had the same immunophenotype as the CLL. FISH 
      analysis revealed gain of c-MYC at 8q and IHC showed increased c-MYC expression. 
      This study supports that c-MYC plays a critical role in RS.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Pathology, University of California San Diego La Jolla, CA 92093, 
      USA.
FAU - Aghel, Azadeh
AU  - Aghel A
AD  - Department of Pathology, University of California San Diego La Jolla, CA 92093, 
      USA.
FAU - Peterson, Brandon
AU  - Peterson B
AD  - Naval Medical Center San Diego, CA 92134 USA.
FAU - Wang-Rodriguez, Jessica
AU  - Wang-Rodriguez J
AD  - Department of Pathology, University of California San Diego La Jolla, CA 92093, 
      USA ; VA Medical Center San Diego, CA 92161, USA.
FAU - Wang, Huan-You
AU  - Wang HY
AD  - Department of Pathology, University of California San Diego La Jolla, CA 92093, 
      USA.
FAU - Zhao, Xianfeng Frank
AU  - Zhao XF
AD  - Department of Pathology, University of California San Diego La Jolla, CA 92093, 
      USA ; VA Medical Center San Diego, CA 92161, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150601
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis/genetics
MH  - Cell Transformation, Neoplastic/chemistry/genetics/*pathology
MH  - Fatal Outcome
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics/*metabolism/pathology/therapy
MH  - Lymphoma, Large B-Cell, Diffuse/*chemistry/genetics/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-myc/*analysis/genetics
MH  - Time Factors
MH  - Treatment Outcome
MH  - Up-Regulation
PMC - PMC4526000
OTO - NOTNLM
OT  - Chronic lymphocytic leukemia/small lymphocytic lymphoma
OT  - MYC
OT  - Richter syndrome
OT  - diffuse large B-cell lymphoma
EDAT- 2015/08/12 06:00
MHDA- 2016/05/18 06:00
PMCR- 2015/06/01
CRDT- 2015/08/12 06:00
PHST- 2015/04/09 00:00 [received]
PHST- 2015/05/26 00:00 [accepted]
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Jun 1;8(6):7540-6. eCollection 2015.