PMID- 26262451
OWN - NLM
STAT- MEDLINE
DCOM- 20160506
LR  - 20161125
IS  - 1538-7151 (Electronic)
IS  - 0277-1691 (Linking)
VI  - 34
IP  - 5
DP  - 2015 Sep
TI  - The Significance of Mismatch Repair Deficiency in Young Patients With Endometrial 
      Cancer.
PG  - 403-10
LID - 10.1097/PGP.0000000000000174 [doi]
AB  - The objective of this study was to identify the tumor characteristics associated 
      with mismatch repair deficiency in young patients with endometrial carcinoma. 
      Young patients (45 yr old or younger) with endometrial carcinoma treated by 
      hysterectomy in our institution between July 2001 and June 2009 were identified. 
      The clinical and pathologic data were obtained by review of clinical records. 
      Among the 122 cases identified, paraffin sections were available in 67 cases for 
      immunohistochemical staining and frozen tissue available in 62 cases for 
      microsatellite instability (MSI) analysis. Both paraffin sections and frozen 
      tissue were available in 36 cases. Among the 67 cases with immunohistochemical 
      staining, 22 (32.8%) showed loss of expression of at least 1 mismatch repair 
      protein. Defective MLH1 or MSH2 expression was associated with poor prognostic 
      factors, including a higher incidence of pelvic lymph nodes metastasis (P=0.018) 
      and higher stage (P=0.022) for MLH1, and an increased risk of lymphovascular 
      permeation (P=0.015) for MSH2. On the contrary, defective MSH6 protein expression 
      was associated with a lower incidence of high-grade tumors (P=0.04). Among the 62 
      cases with MSI analysis, 12 (19.4%) tumors were classified as microsatellite-high 
      (MSI-H), whereas 2 (3.2%) were classified as microsatellite-low (MSI-L). There 
      was no difference in the pathologic characteristics between MSI-stable and MSI-H 
      tumor. We concluded that defective mismatch repair expression is important in 
      young patients with endometrial carcinoma, with MSH6 protein being most commonly 
      affected. The phenotype resulting from defective MSH6 expression was different 
      from that caused by MLH1 or MSH2 loss.
FAU - Chu, Mandy Man-Yee
AU  - Chu MM
AD  - Departments of Obstetrics and Gynecology (M.M.-Y.C., S.S.L., K.-F.T., H.Y.-S.N.) 
      Pathology (P.P.-C.I., A.N.-Y.C.), The University of Hong Kong, Queen Mary 
      Hospital, Hong Kong.
FAU - Liu, Stephanie Si
AU  - Liu SS
FAU - Tam, Kar-Fai
AU  - Tam KF
FAU - Ip, Philip Pun-Ching
AU  - Ip PP
FAU - Cheung, Annie Nga-Yin
AU  - Cheung AN
FAU - Ngan, Hextan Yuen-Sheung
AU  - Ngan HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Gynecol Pathol
JT  - International journal of gynecological pathology : official journal of the 
      International Society of Gynecological Pathologists
JID - 8214845
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (G-T mismatch-binding protein)
RN  - 0 (MLH1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - EC 3.6.1.3 (MSH2 protein, human)
RN  - EC 3.6.1.3 (MutL Protein Homolog 1)
RN  - EC 3.6.1.3 (MutS Homolog 2 Protein)
RN  - Turcot syndrome
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/analysis/genetics
MH  - Adult
MH  - Brain Neoplasms/*genetics/pathology
MH  - Colorectal Neoplasms/*genetics/pathology
MH  - DNA-Binding Proteins/analysis/genetics
MH  - Endometrial Neoplasms/*genetics/pathology/surgery
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Hysterectomy
MH  - Immunohistochemistry
MH  - Lymphatic Metastasis
MH  - Microsatellite Instability
MH  - Middle Aged
MH  - MutL Protein Homolog 1
MH  - MutS Homolog 2 Protein/analysis/genetics
MH  - Neoplasm Staging
MH  - Neoplastic Syndromes, Hereditary/*genetics/pathology
MH  - Nuclear Proteins/analysis/genetics
MH  - Pelvis
MH  - Prognosis
EDAT- 2015/08/12 06:00
MHDA- 2016/05/07 06:00
CRDT- 2015/08/12 06:00
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/05/07 06:00 [medline]
AID - 00004347-201509000-00001 [pii]
AID - 10.1097/PGP.0000000000000174 [doi]
PST - ppublish
SO  - Int J Gynecol Pathol. 2015 Sep;34(5):403-10. doi: 10.1097/PGP.0000000000000174.