PMID- 26262642
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20190108
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 7
IP  - 8
DP  - 2015 Aug 7
TI  - The Long Term Impact of Micronutrient Supplementation during Infancy on Cognition 
      and Executive Function Performance in Pre-School Children.
PG  - 6606-27
LID - 10.3390/nu7085302 [doi]
AB  - Brain growth and development are critically dependent on several micronutrients. 
      During early development cellular activity may be sensitive to micronutrient 
      deficiencies, however the evidence from human studies is equivocal. The objective 
      of this study was to examine the long-term cognitive and social-emotional effects 
      of multiple micronutrient supplementation compared with iron supplementation 
      alone, administered during infancy. This study was a follow-up to an initial 
      randomized, double-blind controlled trial (RCT) in 2010 in which 902 infants, 
      aged 6-17 months, from Lima, Peru, were given daily supplements of either iron 
      (Fe) or multiple micronutrients (MMN) including zinc (451 in each group). The 
      supplementation period for both groups was six months. In 2012, a subsample of 
      184 children from the original cohort (now aged 36-48 months) was randomly 
      selected to participate in a follow-up trial and was assessed for intelligence, 
      working memory, inhibition, and executive function. The tests showed no 
      significant differences between the supplementation groups though there were some 
      gender differences, with girls displaying higher scores than boys across both 
      groups on the Wechsler Preschool and Primary Scale of Intelligence (WPPSI) Verbal 
      IQ sentences subtest, the Day-Night cognitive test and on the Brief 
      Infant-Toddler Social Emotional Assessment (BITSEA) social competency, and boys 
      scoring higher than girls in problem behaviour. The results indicate that MMN 
      supplementation had no long term additional effects on cognitive function 
      compared with iron supplementation alone. The timing of supplement administration 
      for maximum impact on a child's cognitive development requires further 
      investigation.
FAU - Warthon-Medina, Marisol
AU  - Warthon-Medina M
AD  - International Institute of Nutritional Sciences and Applied Food Safety Studies, 
      University of Central Lancashire, Preston PR1 2HE, UK.
FAU - Qualter, Pamela
AU  - Qualter P
AD  - School of Psychology, University of Central Lancashire, Preston PR1 2HE, UK. 
      PQualter@uclan.ac.uk.
FAU - Zavaleta, Nelly
AU  - Zavaleta N
AD  - Instituto de Investigacion Nutricional, Lima, Peru (IIN), Avenida La Universidad, 
      La Molina 1885, Lima 12, Peru. nzavalet@iin.sld.pe.
FAU - Dillon, Stephanie
AU  - Dillon S
AD  - International Institute of Nutritional Sciences and Applied Food Safety Studies, 
      University of Central Lancashire, Preston PR1 2HE, UK. SDillon@uclan.ac.uk.
FAU - Lazarte, Fabiola
AU  - Lazarte F
AD  - Instituto de Investigacion Nutricional, Lima, Peru (IIN), Avenida La Universidad, 
      La Molina 1885, Lima 12, Peru. fabiolalazarte@hotmail.com.
FAU - Lowe, Nicola M
AU  - Lowe NM
AD  - International Institute of Nutritional Sciences and Applied Food Safety Studies, 
      University of Central Lancashire, Preston PR1 2HE, UK. NMLowe@uclan.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150807
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Iron, Dietary)
RN  - 0 (Micronutrients)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - *Child Development
MH  - Child, Preschool
MH  - Cognition/*drug effects
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Executive Function/*drug effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Intelligence/drug effects
MH  - Iron, Dietary/administration & dosage
MH  - Male
MH  - Micronutrients/*administration & dosage
MH  - Peru
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Zinc/administration & dosage
PMC - PMC4555141
OTO - NOTNLM
OT  - cognitive function
OT  - iron
OT  - multiple micronutrient supplementation
OT  - zinc
EDAT- 2015/08/12 06:00
MHDA- 2016/05/20 06:00
PMCR- 2015/08/07
CRDT- 2015/08/12 06:00
PHST- 2015/05/02 00:00 [received]
PHST- 2015/07/03 00:00 [revised]
PHST- 2015/07/22 00:00 [accepted]
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
PHST- 2015/08/07 00:00 [pmc-release]
AID - nu7085302 [pii]
AID - nutrients-07-05302 [pii]
AID - 10.3390/nu7085302 [doi]
PST - epublish
SO  - Nutrients. 2015 Aug 7;7(8):6606-27. doi: 10.3390/nu7085302.