PMID- 26262905
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20221207
IS  - 1557-8992 (Electronic)
IS  - 1044-5463 (Linking)
VI  - 25
IP  - 6
DP  - 2015 Aug
TI  - Adverse Events in Very Young Children Prescribed Psychotropic Medications: 
      Preliminary Findings from an Acute Clinical Sample.
PG  - 509-13
LID - 10.1089/cap.2015.0034 [doi]
AB  - OBJECTIVE: The present study used the Pediatric Adverse Events Rating Scale 
      (PAERS) to provide a systematic assessment of adverse events (AEs) related to 
      psychotropic medication use in a clinical sample of young children attending a 
      specialized, early childhood partial hospital program. Study goals were as 
      follows: 1) To describe the frequency and types of specific psychotropic 
      medication-related AEs experienced by very young children (ages 3-7 years) in an 
      acute clinical sample, and 2) to identify the psychotropic medication(s) and/or 
      class(es) associated with the highest frequency of AEs. METHODS: Participants 
      were 158 children (118 males; ages 36-95 months, mean=66 months, SD=14.6 months) 
      who presented to a hospital-based day treatment program for young children with 
      severe emotional and behavioral problems, and were prescribed a psychotropic 
      medication at any point during the hospitalization. Data on AEs related to 
      psychotropic medication were collected using the PAERS from 2011 to 2014. 
      RESULTS: The percentages of children who experienced one or more AEs attributed 
      to a psychiatric medication ranged from 0 (sertraline, melatonin) to 41.2% 
      (fluoxetine), with wide variability in the types AEs reported. The overall 
      frequencies of events caused by a stimulant were similar across the two 
      medications examined (21.4% and 27.7% for mixed amphetamine salts and 
      methylphenidate, respectively), with mood-related difficulties and decreased 
      appetite being the most common AEs reported. The frequencies of AEs caused by an 
      alpha agonist were also similar across the two medications examined (9.8% and 17.2% 
      for guanfacine and clonidine, respectively), with fatigue as the most commonly 
      reported AE. With respect to the selective serotonin reuptake inhibitor (SSRI) 
      class, there was a trend for fluoxetine to be associated with more AEs (41.2%) 
      than sertraline (for which no AEs were reported). The most common AEs reported 
      for fluoxetine were impulsivity and poor concentration. CONCLUSIONS: The data 
      presented here support existing literature reporting differences in AEs between 
      age groups. More rigorous studies are warranted to further examine the types and 
      frequencies of AEs related to psychotropic medications in very young children.
FAU - Lee, Catherine S
AU  - Lee CS
AD  - 1 Warren Alpert Medical School of Brown University , Department of Child and 
      Adolescent Psychiatry, Providence, Rhode Island.
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
FAU - Williamson, Lauren R
AU  - Williamson LR
AD  - 3 Bradley Hospital , Riverside, Rhode Island.
FAU - Martin, Sarah E
AU  - Martin SE
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
AD  - 4 Simmons College , Boston Massachusetts.
FAU - DeMarco, Mia
AU  - DeMarco M
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
FAU - Majczak, Marta
AU  - Majczak M
AD  - 1 Warren Alpert Medical School of Brown University , Department of Child and 
      Adolescent Psychiatry, Providence, Rhode Island.
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
FAU - Martini, Jane
AU  - Martini J
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
FAU - Hunter, Heather L
AU  - Hunter HL
AD  - 1 Warren Alpert Medical School of Brown University , Department of Child and 
      Adolescent Psychiatry, Providence, Rhode Island.
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
FAU - Fritz, Gregory
AU  - Fritz G
AD  - 1 Warren Alpert Medical School of Brown University , Department of Child and 
      Adolescent Psychiatry, Providence, Rhode Island.
AD  - 3 Bradley Hospital , Riverside, Rhode Island.
FAU - Boekamp, John
AU  - Boekamp J
AD  - 1 Warren Alpert Medical School of Brown University , Department of Child and 
      Adolescent Psychiatry, Providence, Rhode Island.
AD  - 2 Pediatric Partial Hospital Program, Bradley Hospital , Riverside Rhode Island.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Child Adolesc Psychopharmacol
JT  - Journal of child and adolescent psychopharmacology
JID - 9105358
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Mental Disorders/*drug therapy
MH  - Psychotropic Drugs/*adverse effects/therapeutic use
MH  - Selective Serotonin Reuptake Inhibitors/*adverse effects/therapeutic use
EDAT- 2015/08/12 06:00
MHDA- 2016/05/20 06:00
CRDT- 2015/08/12 06:00
PHST- 2015/08/12 06:00 [entrez]
PHST- 2015/08/12 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - 10.1089/cap.2015.0034 [doi]
PST - ppublish
SO  - J Child Adolesc Psychopharmacol. 2015 Aug;25(6):509-13. doi: 
      10.1089/cap.2015.0034.