PMID- 26264639
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20220408
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 20
IP  - 4
DP  - 2016 May
TI  - Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis.
PG  - 745-52
LID - 10.1007/s00784-015-1557-6 [doi]
AB  - OBJECTIVES: The aim of this study was to investigate the relationship the 
      expression of cytokeratins (CK10 and CK13) and the cell proliferation index 
      determined by Ki-67 of lip squamous cell carcinoma and actinic cheilitis with 
      different degrees of dysplasia. MATERIALS AND METHODS: Forty-five 
      paraffin-embedded actinic cheilitis with and without dysplasia and 20 lip 
      squamous cell carcinoma were analyzed by immunohistochemistry using anti-human 
      anti-CK10, anti-CK13, and anti-Ki-67 antibodies. RESULTS: The majority of actinic 
      cheilitis showed immunopositivity for CK10 and CK13 with decrease or loss of 
      expression in dysplastic areas. In lip squamous cell carcinoma of the lip, 
      heterogeneous expression of CK13 and immunonegativity for CK10 were observed. 
      There was a statistically significant difference between CK10 expression in lip 
      squamous cell carcinoma and in actinic cheilitis with or without dysplasia 
      (p < 0.001). The cell proliferation index was higher in actinic cheilitis with 
      dysplasia and lip squamous cell carcinoma than in actinic cheilitis without 
      epithelial dysplasia. A significant correlation was found between the intensity 
      of the epithelial dysplasia and the cell proliferation index (p < 0.001). 
      CONCLUSION: These results provide evidence that there is a downregulation of CK10 
      expression in dysplastic areas of patients with actinic cheilitis and in those 
      with lip squamous cell carcinoma (LSCC) and that the index of cell proliferation, 
      determined by Ki-67, is directly correlated with the intensity of the epithelial 
      dysplasia. CLINICAL RELEVANCE: Altogether, these results suggest that CK10 
      expression and the epithelial cell proliferation index can help to identify 
      malignant transformation in the lip region.
FAU - Garcia, Natalia Galvao
AU  - Garcia NG
AD  - Department of Stomatology, Area of Pathology, Bauru School of Dentistry, 
      University of Sao Paulo, Al. Dr. Octavio Pinheiro Brisolla, 9-75, Bauru, Sao 
      Paulo, 170120-901, Brazil. natggalvao@hotmail.com.
FAU - Oliveira, Denise Tostes
AU  - Oliveira DT
AD  - Department of Stomatology, Area of Pathology, Bauru School of Dentistry, 
      University of Sao Paulo, Al. Dr. Octavio Pinheiro Brisolla, 9-75, Bauru, Sao 
      Paulo, 170120-901, Brazil. denisetostes@usp.br.
FAU - Lauris, Jose Roberto Pereira
AU  - Lauris JR
AD  - Department of Community Dentistry, Bauru School of Dentistry, University of Sao 
      Paulo, Bauru, Sao Paulo, Brazil.
FAU - Domingues, Maria Aparecida Custodio
AU  - Domingues MA
AD  - Department of Pathology, Botucatu School of Medicine, State University of Sao 
      Paulo, Botucatu, Sao Paulo, Brazil.
FAU - Minicucci, Eliana Maria
AU  - Minicucci EM
AD  - Department of Pathology, Botucatu School of Medicine, State University of Sao 
      Paulo, Botucatu, Sao Paulo, Brazil.
FAU - Soares, Cleverson Teixeira
AU  - Soares CT
AD  - Department of Pathology, Lauro de Souza Lima Institute, Bauru, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150813
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 68238-35-7 (Keratins)
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Cell Proliferation
MH  - *Cell Transformation, Neoplastic
MH  - Cheilitis/*metabolism/pathology
MH  - Humans
MH  - Keratins/*metabolism
MH  - Lip Neoplasms/*metabolism
OTO - NOTNLM
OT  - Actinic cheilitis
OT  - Cell proliferation index
OT  - Epithelial dysplasia
OT  - Squamous cell carcinoma of the lip
EDAT- 2015/08/13 06:00
MHDA- 2018/06/23 06:00
CRDT- 2015/08/13 06:00
PHST- 2015/01/24 00:00 [received]
PHST- 2015/07/31 00:00 [accepted]
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
AID - 10.1007/s00784-015-1557-6 [pii]
AID - 10.1007/s00784-015-1557-6 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2016 May;20(4):745-52. doi: 10.1007/s00784-015-1557-6. Epub 
      2015 Aug 13.