PMID- 26265352
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20190907
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 16
IP  - 2
DP  - 2015
TI  - Research Advances in the Treatment of Melanoma by Treat Melanoma.
PG  - 242-50
AB  - Melanoma is a highly malignant tumor. Prognoses of melanoma patients are often 
      unsatisfactory due to poor operational and chemoradiational efficacy. Recently, 
      researches for melanoma treatment have found multipeptide vaccines a favorite and 
      possible breakthrough as they are stable in chemical property and easy to be 
      synthesized, have no carcinogenecity and dispense with virus vector. Studies have 
      shown that the immunogenicity of multipeptide vaccines could be enhanced by use 
      of immunoadjuvants, joining dendritic cells (DCs), full-length or 
      epitope-superposited antigen peptides, costimulatory molecules and 
      cellpenetrating peptides fusion, thereby improving anti-tumor effect. Certain 
      achievements have been obtained in clinical treatment of melanoma by multipeptide 
      vaccines, but problems including poor immunogenicity and human leukocyte antigen 
      (HLA) phenotype restriction may require further study.
FAU - Liu, Can
AU  - Liu C
FAU - He, Si-Qi
AU  - He SQ
FAU - Chen, Xiao-Qing
AU  - Chen XQ
FAU - Xie, Hui-Qing
AU  - Xie HQ
FAU - Chen, Yong
AU  - Chen Y
FAU - Liu, Rui
AU  - Liu R
FAU - Cao, Ke
AU  - Cao K
FAU - Zhou, Jian-Da
AU  - Zhou JD
AD  - Department of Plastic Surgery, the Third Xiangya Hospital, Central South 
      University, Changsha, China. doctorzhoujianda@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - 0 (Cancer Vaccines)
RN  - 0 (Peptides)
SB  - IM
MH  - Cancer Vaccines/immunology/*therapeutic use
MH  - Humans
MH  - Melanoma/*drug therapy/immunology
MH  - Peptides/immunology/*therapeutic use
EDAT- 2015/08/13 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/08/13 06:00
PHST- 2015/06/10 00:00 [received]
PHST- 2015/07/15 00:00 [revised]
PHST- 2015/07/21 00:00 [accepted]
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - CTMC-EPUB-69447 [pii]
AID - 10.2174/1568026615666150812121439 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2015;16(2):242-50. doi: 10.2174/1568026615666150812121439.