PMID- 26266370
OWN - NLM
STAT- MEDLINE
DCOM- 20151104
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 32
DP  - 2015 Aug
TI  - An Attempt to Evaluate Selected Aspects of "Bone-Fat Axis" Function in Healthy 
      Individuals and Patients With Pancreatic Cancer.
PG  - e1303
LID - 10.1097/MD.0000000000001303 [doi]
LID - e1303
AB  - Recently, much attention has been paid to a potential biochemical cross-talk 
      between the metabolism of the adipose tissue (AT) and bone (marrow), termed 
      "bone-fat axis." We hypothesized that selected substances, participating in this 
      "dialog," are associated with body mass and peripheral trafficking of bone 
      marrow-derived stem cells (BMSCs) in both healthy individuals and patients with 
      obesity-associated malignancies such as pancreatic adenocarcinoma.We performed an 
      analysis of the systemic levels of selected substances involved in the regulation 
      of bone (marrow) homeostasis (parathormone, calcitonin, osteopontin, osteonectin, 
      stem cell factor [SCF], and fibroblast growth factor-23) in 35 generally healthy 
      volunteers and 35 patients with pancreatic cancer. Results were correlated with 
      the absolute number of circulating BMSCs and body mass values. Additionally, 
      subcutaneous and visceral/omental AT levels of the aforementioned molecules were 
      analyzed in lean and overweight/obese individuals.Intensified steady-state 
      trafficking of only Lin-CD45 + CD133 + hematopoietic stem/progenitor cells was 
      observed in overweight/obese individuals and this was associated with BMI values 
      and elevated levels of both osteonectin and SCF, which also correlated with BMI. 
      In comparison to healthy individuals, patients with cancer had significantly 
      higher osteopontin levels and lower values of both osteonectin and 
      osteonectin/osteopontin ratio. While no significant correlation was observed 
      between BMI and the number of circulating BMSCs in patients with cancer, 
      peripheral trafficking of CD34 + KDR + CD31 + CD45-endothelial progenitor cells 
      and CD105 + STRO-1 + CD45-mesenchymal stem cells was associated with the 
      osteonectin/osteopontin ratio, which also correlated with BMI (r = 0.52; 
      P < 0.05). AT levels of the examined substances were similar to those measured in 
      the plasma, except for osteonectin, which was about 10 times lower.Our study 
      highlights the potential role of osteonectin, osteopontin, and SCF as 
      communication signals between the bone (marrow) and AT in both healthy 
      individuals and patients with pancreatic cancer. We postulate that these 
      molecules may be overlooked biochemical players linking body mass and BMSCs with 
      obesity-associated cancer development and/or progression in humans.
FAU - Blogowski, Wojciech
AU  - Blogowski W
AD  - From the Department of Internal Medicine, University of Zielona Gora, Zielona 
      Gora, Poland (WB); Department of Laboratory Diagnostics and Molecular Medicine, 
      Pomeranian Medical University, Szczecin, Poland (KD); Department of 
      Gastroenterology, Pomeranian Medical University, Szczecin, Poland (AD); 
      Department of Microbiology and Immunological Diagnostics, Pomeranian Medical 
      University in Szczecin, Szczecin, Poland (BD); and Department of Gastroenterology 
      and Internal Medicine, Warsaw Medical University, Warsaw, Poland (TS).
FAU - Dolegowska, Katarzyna
AU  - Dolegowska K
FAU - Deskur, Anna
AU  - Deskur A
FAU - Dolegowska, Barbara
AU  - Dolegowska B
FAU - Starzynska, Teresa
AU  - Starzynska T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adenocarcinoma/*metabolism
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Bone Marrow Cells/*metabolism
MH  - Endothelial Progenitor Cells/metabolism
MH  - Female
MH  - Hematopoietic Stem Cells/metabolism
MH  - Humans
MH  - Male
MH  - Mesenchymal Stem Cells/metabolism
MH  - Middle Aged
MH  - Obesity/*metabolism
MH  - Pancreatic Neoplasms/*metabolism
PMC - PMC4616689
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2015/08/13 06:00
MHDA- 2015/11/05 06:00
PMCR- 2015/08/14
CRDT- 2015/08/13 06:00
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2015/11/05 06:00 [medline]
PHST- 2015/08/14 00:00 [pmc-release]
AID - 00005792-201508020-00030 [pii]
AID - 10.1097/MD.0000000000001303 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Aug;94(32):e1303. doi: 10.1097/MD.0000000000001303.