PMID- 26266394
OWN - NLM
STAT- MEDLINE
DCOM- 20151104
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 32
DP  - 2015 Aug
TI  - Frequency-Specific Alterations of Local Synchronization in Idiopathic Generalized 
      Epilepsy.
PG  - e1374
LID - 10.1097/MD.0000000000001374 [doi]
LID - e1374
AB  - Recurrently and abnormally hypersynchronous discharge is a striking feature of 
      idiopathic generalized epilepsy (IGE). Resting-state functional magnetic 
      resonance imaging has revealed aberrant spontaneous brain synchronization, 
      predominately in low-frequency range (<0.1 Hz), in individuals with IGE. Little 
      is known, however, about these changes in local synchronization across different 
      frequency bands. We examined alterations to frequency-specific local 
      synchronization in terms of spontaneous blood oxygen level-dependent (BOLD) 
      fluctuations across 5 bands, spanning 0 to 0.25 Hz. Specifically, we compared 
      brain activity in a large cohort of IGE patients (n = 86) to age- and sex-matched 
      normal controls (n = 86). IGE patients showed decreased local synchronization in 
      low frequency (<0.073 Hz), primarily in the default mode network (DMN). IGE 
      patients also exhibited increased local synchronization in high-frequency 
      (>0.073 Hz) in a "conscious perception network," which is anchored by the 
      pregenual and dorsal anterior cingulate cortex, as well as the bilateral insular 
      cortices, possibly contributing to impaired consciousness. Furthermore, we found 
      frequency-specific alternating local synchronization in the posterior portion of 
      the DMN relative to the anterior part, suggesting an interaction between the 
      disease and frequency bands. Importantly, the aberrant high-frequency local 
      synchronization in the middle cingulate cortex was associated with disease 
      duration, thus linking BOLD frequency changes to disease severity. These findings 
      provide an overview of frequency-specific local synchronization of BOLD 
      fluctuations, and may be helpful in uncovering abnormal synchronous neuronal 
      activity in patients with IGE at specific frequency bands.
FAU - Wang, Jue
AU  - Wang J
AD  - From the Center for Cognition and Brain Disorders and the Affiliated Hospital 
      (JW, G-JJ, Y-FZ, WL), Hangzhou Normal University; Zhejiang Key Laboratory for 
      Research in Assessment of Cognitive Impairments (JW, G-JJ, Y-FZ, WL), Hangzhou; 
      Department of Medical Imaging (ZZ, QX, YH, WL, GL), Jinling Hospital, Nanjing 
      University School of Medicine; Department of Medical Imaging (ZW), Nanjing Drum 
      Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 
      Nanjing; Department of Radiology (QJ), Taishan Medical University, Tai'an; and 
      Department of Neurology (FY), Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Zhang, Zhiqiang
AU  - Zhang Z
FAU - Ji, Gong-Jun
AU  - Ji GJ
FAU - Xu, Qiang
AU  - Xu Q
FAU - Huang, Yubin
AU  - Huang Y
FAU - Wang, Zhengge
AU  - Wang Z
FAU - Jiao, Qing
AU  - Jiao Q
FAU - Yang, Fang
AU  - Yang F
FAU - Zang, Yu-Feng
AU  - Zang YF
FAU - Liao, Wei
AU  - Liao W
FAU - Lu, Guangming
AU  - Lu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - Epilepsy, Idiopathic Generalized
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*pathology
MH  - Epilepsy, Generalized/*pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Oximetry
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC4616718
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2015/08/13 06:00
MHDA- 2015/11/05 06:00
PMCR- 2015/08/14
CRDT- 2015/08/13 06:00
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2015/11/05 06:00 [medline]
PHST- 2015/08/14 00:00 [pmc-release]
AID - 00005792-201508020-00054 [pii]
AID - 10.1097/MD.0000000000001374 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Aug;94(32):e1374. doi: 10.1097/MD.0000000000001374.