PMID- 26266406
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 16
IP  - 8
DP  - 2015 Aug 10
TI  - Role of Pharmacogenetics in Hematopoietic Stem Cell Transplantation Outcome in 
      Children.
PG  - 18601-27
LID - 10.3390/ijms160818601 [doi]
AB  - Hematopoietic stem cell transplantation (HSCT) is an established therapeutic 
      procedure for several congenital and acquired disorders, both malignant and 
      nonmalignant. Despite the great improvements in HSCT clinical practices over the 
      last few decades, complications, such as graft vs. host disease (GVHD) and 
      sinusoidal obstructive syndrome (SOS), are still largely unpredictable and remain 
      the major causes of morbidity and mortality. Both donor and patient genetic 
      background might influence the success of bone marrow transplantation and could 
      at least partially explain the inter-individual variability in HSCT outcome. This 
      review summarizes some of the recent studies on candidate gene polymorphisms in 
      HSCT, with particular reference to pediatric cohorts. The interest is especially 
      focused on pharmacogenetic variants affecting myeloablative and immunosuppressive 
      drugs, although genetic traits involved in SOS susceptibility and 
      transplant-related mortality are also reviewed.
FAU - Franca, Raffaella
AU  - Franca R
AD  - Institute for Maternal and Child Health (I.R.C.C.S.) Burlo Garofolo, UO Pediatric 
      Hemato-Oncology, Trieste 34137, Italy. rfranca@units.it.
FAU - Stocco, Gabriele
AU  - Stocco G
AD  - Department of Life Sciences, University of Trieste, Trieste 34127, Italy. 
      stoccog@units.it.
FAU - Favretto, Diego
AU  - Favretto D
AD  - Institute for Maternal and Child Health (I.R.C.C.S.) Burlo Garofolo, UO Pediatric 
      Hemato-Oncology, Trieste 34137, Italy. dieg.o@libero.it.
FAU - Giurici, Nagua
AU  - Giurici N
AD  - Institute for Maternal and Child Health (I.R.C.C.S.) Burlo Garofolo, UO Pediatric 
      Hemato-Oncology, Trieste 34137, Italy. nagua.giurici@burlo.trieste.it.
FAU - Decorti, Giuliana
AU  - Decorti G
AD  - Department of Life Sciences, University of Trieste, Trieste 34127, Italy. 
      decorti@units.it.
FAU - Rabusin, Marco
AU  - Rabusin M
AD  - Institute for Maternal and Child Health (I.R.C.C.S.) Burlo Garofolo, UO Pediatric 
      Hemato-Oncology, Trieste 34137, Italy. marco.rabusin@burlo.trieste.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150810
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Child
MH  - Graft vs Host Disease/drug therapy/epidemiology/*genetics
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*methods
MH  - Hepatic Veno-Occlusive Disease/drug therapy/epidemiology/*genetics
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Pharmacogenetics/*methods
MH  - Polymorphism, Genetic
MH  - Treatment Outcome
PMC - PMC4581262
OTO - NOTNLM
OT  - graft vs. host disease
OT  - hematopoietic stem cell transplantation
OT  - pharmacogenetics
OT  - sinusoidal obstructive syndrome
EDAT- 2015/08/13 06:00
MHDA- 2016/05/10 06:00
PMCR- 2015/08/01
CRDT- 2015/08/13 06:00
PHST- 2015/06/13 00:00 [received]
PHST- 2015/06/21 00:00 [revised]
PHST- 2015/07/28 00:00 [accepted]
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - ijms160818601 [pii]
AID - ijms-16-18601 [pii]
AID - 10.3390/ijms160818601 [doi]
PST - epublish
SO  - Int J Mol Sci. 2015 Aug 10;16(8):18601-27. doi: 10.3390/ijms160818601.