PMID- 26266889
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20150813
IS  - 1533-404X (Electronic)
IS  - 0195-7910 (Linking)
VI  - 36
IP  - 3
DP  - 2015 Sep
TI  - Axonal Injury in Stroke: A Forensic Neuropathology Perspective.
PG  - 172-5
LID - 10.1097/PAF.0000000000000166 [doi]
AB  - The use of beta-amyloid precursor protein (beta-APP) immunocytochemistry is standard 
      practice in forensic neuropathology to assess the presence and severity of 
      traumatic axonal injury. However, axonal injury has many causes, in addition to 
      trauma. The principal complicating factor in interpretation is where traumatic 
      brain injury is associated with brain swelling or hemorrhage, resulting in 
      ischemic axonal injury. Although it has been claimed that different patterns of 
      beta-APP immunoreactivity are seen in trauma, as opposed to hypoxia-ischemia, there 
      have been few systematic studies of beta-APP immunostaining patterns in ischemic or 
      hemorrhagic stroke. This study investigated staining patterns in 96 cases of 
      stroke with no history of head injury and found complex staining patterns, some 
      of which were indistinguishable from those said to be specific for trauma. A 
      questioning approach to the assessment of beta-APP immunostaining patterns in cases 
      of head injury is proposed to ensure that the possibility of some or much of the 
      staining being due to ischemia has been excluded, before concluding that the 
      axonal injury identified is traumatic in causation.
FAU - MacKenzie, James Mackintosh
AU  - MacKenzie JM
AD  - From the Department of Pathology, University Medical School Foresterhill, 
      Aberdeen, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Forensic Med Pathol
JT  - The American journal of forensic medicine and pathology
JID - 8108948
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Axons/pathology
MH  - Biomarkers/metabolism
MH  - Brain/metabolism
MH  - Diffuse Axonal Injury/*pathology
MH  - Forensic Pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Stroke/*pathology
MH  - White Matter/pathology
EDAT- 2015/08/13 06:00
MHDA- 2016/05/25 06:00
CRDT- 2015/08/13 06:00
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
AID - 00000433-201509000-00011 [pii]
AID - 10.1097/PAF.0000000000000166 [doi]
PST - ppublish
SO  - Am J Forensic Med Pathol. 2015 Sep;36(3):172-5. doi: 
      10.1097/PAF.0000000000000166.