PMID- 26267061
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150813
LR  - 20220410
IS  - 2211-8020 (Print)
IS  - 2211-8039 (Electronic)
IS  - 2211-8020 (Linking)
VI  - 5
IP  - 3
DP  - 2015 Sep
TI  - The development of bioactive peptides from dietary proteins as a dipeptidyl 
      peptidase IV inhibitor for the management of type 2 diabetes.
PG  - 14
LID - 10.7603/s40681-015-0014-9 [doi]
LID - 14
AB  - One of the new approaches to the management of type 2 diabetes mellitus (T2DM) 
      consists of orally administered dipeptidyl peptidase-IV (DPP-IV) inhibitors. 
      These synthetic drug inhibitors are reported to have some side effects and that 
      subsequently limits their applications. There is a growing interest to develop 
      natural DPP-IV inhibitors that will be potent without undesirable side effects. 
      Many in vitro and some in vivo studies have highlighted the potential of 
      food-derived peptides functioning as effective DPPIV inhibitors. Bioactive 
      peptides within original food-derived proteins are inactive but can be activated 
      by being released during food processing (by enzymatic hydrolysis or 
      fermentation) or during gastrointestinal digestion. Hence, the utilization of 
      computer-aided techniques as screening tools may be helpful in predicting the 
      potential of food proteins as precursors of DPP-IV inhibitory peptides. This 
      paper reviews the current literature on DPP-IV inhibitory peptides, focusing on 
      their in vitro activity and in vivo antidiabetic effects. In addition, the 
      feasibility of various in silico approaches is also summarized in this review.
FAU - Jao, Chia-Ling
AU  - Jao CL
AD  - Department of Food and Beverage Management, Tung-Fang Design University, No. 110, 
      Tung-Fang Road, 829, Kaohsiung, Taiwan.
FAU - Hung, Chuan-Chuan
AU  - Hung CC
FAU - Tung, Yu-Shan
AU  - Tung YS
FAU - Lin, Pei-Yi
AU  - Lin PY
FAU - Chen, Meng-Chun
AU  - Chen MC
FAU - Hsu, Kuo-Chiang
AU  - Hsu KC
LA  - eng
PT  - Journal Article
DEP - 20150813
PL  - China (Republic : 1949- )
TA  - Biomedicine (Taipei)
JT  - BioMedicine
JID - 101611451
PMC - PMC4534476
EDAT- 2015/08/13 06:00
MHDA- 2015/08/13 06:01
PMCR- 2015/08/13
CRDT- 2015/08/13 06:00
PHST- 2015/05/18 00:00 [received]
PHST- 2015/06/25 00:00 [accepted]
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2015/08/13 06:01 [medline]
PHST- 2015/08/13 00:00 [pmc-release]
AID - 14 [pii]
AID - 10.7603/s40681-015-0014-9 [doi]
PST - ppublish
SO  - Biomedicine (Taipei). 2015 Sep;5(3):14. doi: 10.7603/s40681-015-0014-9. Epub 2015 
      Aug 13.