PMID- 26267660
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20151027
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 93
IP  - 7
DP  - 2015 Nov
TI  - Detection of retinal changes in idiopathic Parkinson's disease using 
      high-resolution optical coherence tomography and heidelberg retina tomography.
PG  - e578-84
LID - 10.1111/aos.12757 [doi]
AB  - PURPOSE: The study was performed to analyse the retina of patients with 
      Parkinson's disease (PD) for morphological changes compared to healthy controls 
      (HC) using spectral-domain optical coherence tomography (SD-OCT) and confocal 
      scanning laser ophthalmoscopy. METHODS: We enrolled 108 patients with idiopathic 
      PD and 165 HC. All study participants underwent an ophthalmological examination 
      to exclude ophthalmological disorder potentially interfering with the retinal 
      analyses. Peripapillary retinal nerve fibre layer (RNFL) thickness and macular 
      thickness and volume were measured by a SD-OCT device (Heidelberg Spectralis((R)) 
      ). Stereometric parameters of the optic disc were acquired by Heidelberg Retina 
      Tomograph (HRT III). RESULTS: The RNFL thickness did not significantly differ 
      between patients with PD and HC. The thickness of the central minimum and the 
      centre of the macular area were significantly reduced in patients with PD, while 
      the total macular volume did not significantly differ between the groups. 
      Furthermore, we noted an inverse correlation between the central minimum 
      thickness and the disease severity (assessed by the Hoehn and Yahr scale). HRT 
      data showed no significant differences. CONCLUSION: The HRT device and the RNFL 
      measurements of the SD-OCT did not prove to be a clinically valid diagnostic tool 
      to distinguish eyes of patients with PD and HC. However, the macular region and 
      especially the foveola (central minimum) with the highest density of 
      photoreceptor cells seem to be more sensitive and might be potential biomarkers.
CI  - (c) 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Bittersohl, Diana
AU  - Bittersohl D
AD  - Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Stemplewitz, Birthe
AU  - Stemplewitz B
AD  - Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Keseru, Matthias
AU  - Keseru M
AD  - Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Buhmann, Carsten
AU  - Buhmann C
AD  - Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, 
      Germany.
FAU - Richard, Gisbert
AU  - Richard G
AD  - Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Hassenstein, Andrea
AU  - Hassenstein A
AD  - Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20150610
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Ophthalmoscopy
MH  - Parkinson Disease/*diagnosis
MH  - Prospective Studies
MH  - Retinal Diseases/*diagnosis
MH  - Retinal Ganglion Cells/*pathology
MH  - *Tomography, Optical Coherence
MH  - Young Adult
OTO - NOTNLM
OT  - Heidelberg retina tomography
OT  - Parkinson's disease
OT  - Spectral-domain optical coherence tomography
OT  - retinal nerve fibre layer
EDAT- 2015/08/13 06:00
MHDA- 2016/05/20 06:00
CRDT- 2015/08/13 06:00
PHST- 2014/10/15 00:00 [received]
PHST- 2015/04/06 00:00 [accepted]
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - 10.1111/aos.12757 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2015 Nov;93(7):e578-84. doi: 10.1111/aos.12757. Epub 2015 Jun 
      10.