PMID- 26267666
OWN - NLM
STAT- MEDLINE
DCOM- 20161103
LR  - 20181202
IS  - 1619-0904 (Electronic)
IS  - 1434-7229 (Linking)
VI  - 19
IP  - 1
DP  - 2016 Mar
TI  - Improved clinical course of autologous skeletal myoblast sheet (TCD-51073) 
      transplantation when compared to a propensity score-matched cardiac 
      resynchronization therapy population.
PG  - 80-6
LID - 10.1007/s10047-015-0862-9 [doi]
AB  - We recently reported a multi-center, single-arm, phase II study that evaluated 
      the efficacy and safety of autologous skeletal myoblast sheet (TCD-51073) 
      transplantation. The advantage of this procedure over a control group has not yet 
      been analyzed. Seven patients with advanced heart failure due to ischemic 
      etiology (TCD-51073 group, New York Heart Association (NYHA) class III; left 
      ventricular ejection fraction (LVEF) <35 %) refractory to optimal medical and 
      coronary revascularization therapy, received TCD-51073 at 3 study centers between 
      2012 and 2013 with a 2-year follow-up period. As previously reported, 112 
      patients received cardiac resynchronization therapy (CRT) with follow-up at the 
      University of Tokyo Hospital between 2007 and 2014. Of them, 21 patients were 
      selected for the control group by propensity score matching. No significant 
      difference in baseline variables between the groups was observed. LVEF and NYHA 
      class improved significantly in the TCD-51073 group during the 6-month study 
      period (p < 0.05). During the 2-year follow-up, 7 patients (33 %) in the CRT 
      group and no patient in the TCD-51073 group died due to cardiac disease or 
      received VAD implantation (p = 0.128 by the log-rank test). In conclusion, 
      transplantation of TCD-51073 is clinically advantageous in facilitating LV 
      reverse remodeling, improving HF symptoms, and preventing cardiac death in 
      patients with ischemic etiology when compared to background-matched patients 
      receiving CRT.
FAU - Imamura, Teruhiko
AU  - Imamura T
AD  - Department of Therapeutic Strategy for Heart Failure, Graduate School of 
      Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. 
      imamurate-int@h.u-tokyo.ac.jp.
FAU - Kinugawa, Koichiro
AU  - Kinugawa K
AD  - Department of Therapeutic Strategy for Heart Failure, Graduate School of 
      Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. 
      kinugawa-tky@umin.ac.jp.
FAU - Sakata, Yasushi
AU  - Sakata Y
AD  - Department of Cardiovascular Medicine, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Miyagawa, Shigeru
AU  - Miyagawa S
AD  - Department of Cardiovascular Surgery, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Sawa, Yoshiki
AU  - Sawa Y
AD  - Department of Cardiovascular Surgery, Osaka University Graduate School of 
      Medicine, Osaka, Japan.
FAU - Yamazaki, Kenji
AU  - Yamazaki K
AD  - Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, 
      Japan.
FAU - Ono, Minoru
AU  - Ono M
AD  - Department of Cardiac Surgery, Graduate School of Medicine, University of Tokyo, 
      Tokyo, Japan.
LA  - eng
SI  - JPRN/UMIN000008013
PT  - Journal Article
DEP - 20150813
PL  - Japan
TA  - J Artif Organs
JT  - Journal of artificial organs : the official journal of the Japanese Society for 
      Artificial Organs
JID - 9815648
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Heart Failure/etiology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myoblasts, Skeletal/*transplantation
MH  - Myocardial Ischemia/complications/*therapy
MH  - Propensity Score
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Cardiac death
OT  - Heart failure
OT  - Ischemic cardiomyopathy
OT  - Regeneration
OT  - Skeletal myoblast transplantation
EDAT- 2015/08/13 06:00
MHDA- 2016/11/04 06:00
CRDT- 2015/08/13 06:00
PHST- 2015/06/08 00:00 [received]
PHST- 2015/08/04 00:00 [accepted]
PHST- 2015/08/13 06:00 [entrez]
PHST- 2015/08/13 06:00 [pubmed]
PHST- 2016/11/04 06:00 [medline]
AID - 10.1007/s10047-015-0862-9 [pii]
AID - 10.1007/s10047-015-0862-9 [doi]
PST - ppublish
SO  - J Artif Organs. 2016 Mar;19(1):80-6. doi: 10.1007/s10047-015-0862-9. Epub 2015 
      Aug 13.