PMID- 26268737
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20170428
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 126
IP  - 9
DP  - 2016 Sep
TI  - Do different reperfusion methods affect the outcomes of stroke induced by MCAO in 
      adult rats?
PG  - 850-5
LID - 10.3109/00207454.2015.1074903 [doi]
AB  - There are two patterns of ischemia/reperfusion (I/R) models used in rat middle 
      cerebral artery occlusion (MCAO) I/R models, which differ in the use of 
      unilateral or bilateral carotid artery reperfusion. The primary difference 
      between the two patterns of I/R models is the complexity of the surgery 
      procedure. However, researchers in this field have no idea whether there are any 
      differences in outcomes of these two methods. In this study, we investigated the 
      effects of the two methods on neurological deficits, infarct volume, blood-brain 
      barrier (BBB) integrity and brain derived neurotrophic factor (BDNF) expression. 
      Through evaluating the current way of bilateral common carotid artery 
      reperfusion, we tried to find whether it could be replaced by an easier way. We 
      found that there were no statistical significant differences between the 
      different methods in infarct volume, neurological deficits, BBB integrity, and 
      the level of BDNF (P > 0.05). These data demonstrated that different methods did 
      not affect the neurological deficits, infarct volume, BBB integrity, and the BDNF 
      protein level, which provides reference when we use an experimental stroke. These 
      results suggest that the two methods have similar capability for inducing 
      cerebral I/R injury and can be interchanged.
FAU - Zuo, Xia-Lin
AU  - Zuo XL
AD  - a 1 Institute of Neurosciences and the Second Affiliated Hospital , Guangzhou 
      Medical University , Guangzhou , P.R. China.
FAU - Deng, Hou-Liang
AU  - Deng HL
AD  - b 2 Center for Drug Research and Development, zhujiang Hospital , Southern 
      Medical University , Guangzhou , P.R. China.
FAU - Wu, Ping
AU  - Wu P
AD  - b 2 Center for Drug Research and Development, zhujiang Hospital , Southern 
      Medical University , Guangzhou , P.R. China.
FAU - Xu, En
AU  - Xu E
AD  - a 1 Institute of Neurosciences and the Second Affiliated Hospital , Guangzhou 
      Medical University , Guangzhou , P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150813
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Disease Models, Animal
MH  - *Infarction, Middle Cerebral Artery/metabolism/pathology/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Reperfusion Injury/metabolism/pathology/physiopathology
MH  - *Stroke/metabolism/pathology/physiopathology
OTO - NOTNLM
OT  - experimental stroke model
OT  - ischemia/reperfusion
OT  - middle cerebral artery occlusion
OT  - stroke
EDAT- 2015/08/14 06:00
MHDA- 2017/04/30 06:00
CRDT- 2015/08/14 06:00
PHST- 2015/08/14 06:00 [entrez]
PHST- 2015/08/14 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
AID - 10.3109/00207454.2015.1074903 [pii]
AID - 10.3109/00207454.2015.1074903 [doi]
PST - ppublish
SO  - Int J Neurosci. 2016 Sep;126(9):850-5. doi: 10.3109/00207454.2015.1074903. Epub 
      2015 Aug 13.