PMID- 26268819
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 87
IP  - 3
DP  - 2016 Feb 15
TI  - Long-term survival and preprocedural predictors of mortality in high surgical 
      risk patients undergoing percutaneous mitral valve repair.
PG  - 467-75
LID - 10.1002/ccd.26137 [doi]
AB  - OBJECTIVES: To evaluate long-term survival in high surgical risk patients 
      undergoing percutaneous mitral valve repair (MVR) using the MitraClip((R)) system 
      and to identify preprocedural predictors of long-term mortality. BACKGROUND: Data 
      for long-term survival and preprocedural predictors of mortality after 
      percutaneous MVR in high surgical risk patients are sporadic. METHODS: From 
      January 2009 to April 2013, 136 consecutive high surgical risk patients, with 
      symptomatic moderate-to-severe or severe mitral regurgitation (MR), underwent 
      percutaneous MVR using the MitraClip system. Cardiac and overall survival was 
      determined at one and 2 years postprocedure. Univariate and multivariate analysis 
      was performed to identify preprocedural predictors of long-term mortality. 
      RESULTS: One year postprocedure, cardiac and overall survival was 86.7% and 
      84.6%, respectively and at 2 years cardiac and overall survival was 77.7% and 
      74.8%, respectively. In univariate analysis advanced age, lower body mass index, 
      impaired renal function, elevated levels of 
      log-N-terminal-pro-brain-natriuretic-peptide (log-NTproBNP), poor performance in 
      functional tests (New York Heart Association (NYHA) class) and high logistic 
      Euroscore (LES) and Society of Thoracic Surgeons (STS) score were identified as 
      preprocedural predictors of long-term cardiac mortality. In multivariate analysis 
      preoperative NYHA class III and IV, elevated levels of log-NTproBNP and advanced 
      age predicted long-term cardiac mortality. CONCLUSIONS: Percutaneous MVR using 
      the MitraClip system has favorable long-term survival rates in high surgical risk 
      patients. Preprocedural NYHA functional class III and IV, elevated log-NTproBNP 
      levels and advanced age predict higher long-term cardiac mortality and should be 
      considered during patient selection.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Triantafyllis, Andreas S
AU  - Triantafyllis AS
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Kortlandt, Friso
AU  - Kortlandt F
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Bakker, Annelies L M
AU  - Bakker AL
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Swaans, Martin J
AU  - Swaans MJ
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Eefting, Frank D
AU  - Eefting FD
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - van der Heyden, Jan A S
AU  - van der Heyden JA
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Post, Martijn C
AU  - Post MC
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Rensing, Benno W J M
AU  - Rensing BW
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150813
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
CIN - Catheter Cardiovasc Interv. 2016 Feb 15;87(3):476-7. PMID: 26919343
MH  - Aged
MH  - Cardiac Catheterization/adverse effects/instrumentation/*mortality
MH  - Female
MH  - Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/adverse effects/instrumentation/*mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - *Mitral Valve/physiopathology
MH  - Mitral Valve Insufficiency/diagnosis/mortality/physiopathology/*therapy
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Prosthesis Design
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - mitral valve disease-edge to edge repair
EDAT- 2015/08/14 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/08/14 06:00
PHST- 2014/10/11 00:00 [received]
PHST- 2015/04/29 00:00 [revised]
PHST- 2015/07/11 00:00 [accepted]
PHST- 2015/08/14 06:00 [entrez]
PHST- 2015/08/14 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1002/ccd.26137 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2016 Feb 15;87(3):467-75. doi: 10.1002/ccd.26137. 
      Epub 2015 Aug 13.