PMID- 26269254
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150813
LR  - 20220330
IS  - 1931-7573 (Print)
IS  - 1556-276X (Electronic)
IS  - 1556-276X (Linking)
VI  - 10
IP  - 1
DP  - 2015 Dec
TI  - Toxicological effect of TiO2 nanoparticle-induced myocarditis in mice.
PG  - 1029
LID - 10.1186/s11671-015-1029-6 [doi]
LID - 326
AB  - Currently, impacts of exposure to TiO2 nanoparticles (NPs) on the cardiovascular 
      system are not well understood. The aim of this study was to investigate whether 
      TiO2 NPs induce myocarditis and its underlying molecular mechanism in the cardiac 
      inflammation in mice. Mice were exposed to TiO2 NPs for 6 months; biochemical 
      parameters of serum and expression of Th1-related and Th2-related cytokines in 
      the heart were investigated. The results showed that TiO2 NP exposure resulted in 
      cardiac lesions coupling with pulmonary inflammation; increases of aspartate 
      aminotransferase (AST), creatine kinase (CK), C-reaction protein (CRP), lactate 
      dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (HBDH), adhesion 
      molecule-1 (ICAM-1), and monocyte chemoattractant protein-1 (MCP-1) levels; and a 
      reduction of nitric oxide (NOx) level in the serum. These were associated with 
      increases of nuclear factor-kappaB (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), 
      interleukin (IL)-4, IL-6, transforming growth factor-beta (TGF-beta), creatine kinase, 
      CRP, adhesion molecule-1, and monocyte chemoattractant protein-1, interferon-gamma 
      (IFN-gamma), signal transducers and activators of transcription (STAT)1, STAT3, or 
      STAT6, GATA-binding domain-3, GATA-binding domain-4, endothelin-1 expression 
      levels, and T-box expressed in T cells expression level that is the master 
      regulator of pro-inflammatory cytokines and transcription factors in the heart. 
      These findings imply that TiO2 NP exposure may increase the occurrence and 
      development of cardiovascular diseases.
FAU - Hong, Fashui
AU  - Hong F
AD  - Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & 
      Environmental Protection, Huaiyin Normal University, Huaian, 223300, China, 
      hfshui666@126.com.
FAU - Wang, Ling
AU  - Wang L
FAU - Yu, Xiaohong
AU  - Yu X
FAU - Zhou, Yingjun
AU  - Zhou Y
FAU - Hong, Jie
AU  - Hong J
FAU - Sheng, Lei
AU  - Sheng L
LA  - eng
PT  - Journal Article
DEP - 20150814
PL  - United States
TA  - Nanoscale Res Lett
JT  - Nanoscale research letters
JID - 101279750
PMC - PMC4534482
EDAT- 2015/08/14 06:00
MHDA- 2015/08/14 06:01
PMCR- 2015/08/14
CRDT- 2015/08/14 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/07/30 00:00 [accepted]
PHST- 2015/08/14 06:00 [entrez]
PHST- 2015/08/14 06:00 [pubmed]
PHST- 2015/08/14 06:01 [medline]
PHST- 2015/08/14 00:00 [pmc-release]
AID - 1029 [pii]
AID - 10.1186/s11671-015-1029-6 [doi]
PST - ppublish
SO  - Nanoscale Res Lett. 2015 Dec;10(1):1029. doi: 10.1186/s11671-015-1029-6. Epub 
      2015 Aug 14.