PMID- 26269338
OWN - NLM
STAT- MEDLINE
DCOM- 20160722
LR  - 20181202
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 43
IP  - 3
DP  - 2015 Mar
TI  - [Peak oxygen consumption, NT-proBNP and echocardiographic changes in patients 
      with chronic heart failure].
PG  - 206-11
AB  - OBJECTIVE: To assess peak oxygen consumption (peak VO(2)) derived from 
      cardiopulmonary exercise testing (CPET), concentrations of NT-proBNP and 
      echocardiographic changes in patients with chronic heart failure (CHF) and 
      reduced left ventricular ejection fraction (LVEF, <40%). METHODS: Seventy 
      patients were included and divided into two groups according to the New York 
      Heart Association (NYHA) classification: NYHA II group (17 cases) and NYHA III-IV 
      group (53 cases). The basic clinical information, plasma concentration of 
      NT-proBNP at rest, echocardiographic parameters and peak VO(2)from CPET were 
      compared between two groups. Correlation among peak VO(2), NT-proBNP and 
      echocardiographic parameters in this patient cohort was assessed and their 
      abilities to discriminate the NYHA III-IV grade were analyzed through 
      c-Statistic. RESULTS: Left atrial diameter ((51.3 +/- 7.2) mm vs. (44.0+/-7.4) mm, 
      P<0.001) was larger, plasma concentration of NT-proBNP (1 379-4 399 pmol/L vs. 1 
      109-2 356 pmol/L, P<0.01) was higher and peak VO(2)((13.4 +/- 3.5) ml.kg(-)(1).min(-)(1) vs. 
      (18.2 +/- 3.7) ml.kg(-)(1).min(-)(1), P<0.001) were significantly lower in NYHA III-IV 
      group than those in NYHA II group. However, left ventricular end-diastolic 
      diameter (LVEDD) and LVEF were similar between two groups. Peak VO(2)correlated 
      significantly with NT-proBNP (r=-0.311, P<0.01), but neither peak VO(2)nor 
      NT-proBNP correlated with echocardiographic parameters (LA, LVEDD and LVEF). ROC 
      analysis showed that peak VO(2)had the strongest discriminatory power for detecting 
      NYHA III-IV grade patients (AUC=0.835, P<0.001), followed by the NT-proBNP 
      (AUC=0.723, P<0.01). CONCLUSION: Peak VO(2)is a more sensitive parameter to detect 
      the disease aggravation (NYHA III-IV grade) of the CHF patients with reduced LVEF 
      compared to plasma NT-proBNP and echocardiographic parameters (LA, LVEDD, LVEF).
FAU - Lu, Zhinan
AU  - Lu Z
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100037, China.
FAU - Sun, Xingguo
AU  - Sun X
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100037, China; Email: xgsun@labiomed.org.
FAU - Hu, Shengshou
AU  - Hu S
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100037, China.
FAU - Huang, Jie
AU  - Huang J
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100037, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Chronic Disease
MH  - *Echocardiography
MH  - Exercise Test
MH  - Heart
MH  - *Heart Failure
MH  - Humans
MH  - Natriuretic Peptide, Brain
MH  - *Oxygen Consumption
MH  - Peptide Fragments
MH  - ROC Curve
MH  - Ventricular Function, Left
EDAT- 2015/08/14 06:00
MHDA- 2016/07/23 06:00
CRDT- 2015/08/14 06:00
PHST- 2015/08/14 06:00 [entrez]
PHST- 2015/08/14 06:00 [pubmed]
PHST- 2016/07/23 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Mar;43(3):206-11.