PMID- 26269592
OWN - NLM
STAT- MEDLINE
DCOM- 20151217
LR  - 20210205
IS  - 1083-351X (Electronic)
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 290
IP  - 39
DP  - 2015 Sep 25
TI  - Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor.
PG  - 23997-4006
LID - 10.1074/jbc.M115.653378 [doi]
AB  - Improper signaling of the IL-36 receptor (IL-36R), a member of the IL-1 receptor 
      family, has been associated with various inflammation-associated diseases. 
      However, the requirements for IL-36R signal transduction remain poorly 
      characterized. This work seeks to define the requirements for IL-36R signaling 
      and intracellular trafficking. In the absence of cognate agonists, IL-36R was 
      endocytosed and recycled to the plasma membrane. In the presence of IL-36, IL-36R 
      increased accumulation in LAMP1+ lysosomes. Endocytosis predominantly used a 
      clathrin-mediated pathway, and the accumulation of the IL-36R in lysosomes did 
      not result in increased receptor turnover. The ubiquitin-binding Tollip protein 
      contributed to IL-36R signaling and increased the accumulation of both subunits 
      of the IL-36R.
CI  - (c) 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
FAU - Saha, Siddhartha S
AU  - Saha SS
AD  - From the Department of Molecular and Cellular Biochemistry, Indiana University, 
      Bloomington, Indiana 47401 and.
FAU - Singh, Divyendu
AU  - Singh D
AD  - From the Department of Molecular and Cellular Biochemistry, Indiana University, 
      Bloomington, Indiana 47401 and.
FAU - Raymond, Ernest L
AU  - Raymond EL
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Ganesan, Rajkumar
AU  - Ganesan R
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Caviness, Gary
AU  - Caviness G
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Grimaldi, Christine
AU  - Grimaldi C
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Woska, Joseph R Jr
AU  - Woska JR Jr
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Mennerich, Detlev
AU  - Mennerich D
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Brown, Su-Ellen
AU  - Brown SE
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877.
FAU - Mbow, M Lamine
AU  - Mbow ML
AD  - Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877 
      lamine.mbow@boehringer-ingelheim.com.
FAU - Kao, C Cheng
AU  - Kao CC
AD  - From the Department of Molecular and Cellular Biochemistry, Indiana University, 
      Bloomington, Indiana 47401 and ckao@indiana.edu.
LA  - eng
PT  - Journal Article
DEP - 20150812
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Interleukin-1)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (TOLLIP protein, human)
RN  - 0 (interleukin 36, human)
RN  - 0 (interleukin-36 receptor, human)
SB  - IM
MH  - Cell Line
MH  - Endocytosis/*physiology
MH  - Humans
MH  - Interleukin-1/genetics/*metabolism
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Lysosomes/genetics/*metabolism
MH  - Protein Transport/physiology
MH  - Receptors, Interleukin/genetics/*metabolism
MH  - Signal Transduction/*physiology
PMC - PMC4583048
OTO - NOTNLM
OT  - IL-1
OT  - Tollip
OT  - endocytosis
OT  - immunology
OT  - interleukin 36 receptor
OT  - signal transduction
OT  - trafficking
EDAT- 2015/08/14 06:00
MHDA- 2015/12/19 06:00
PMCR- 2016/09/25
CRDT- 2015/08/14 06:00
PHST- 2015/03/19 00:00 [received]
PHST- 2015/08/14 06:00 [entrez]
PHST- 2015/08/14 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
PHST- 2016/09/25 00:00 [pmc-release]
AID - S0021-9258(20)44734-9 [pii]
AID - M115.653378 [pii]
AID - 10.1074/jbc.M115.653378 [doi]
PST - ppublish
SO  - J Biol Chem. 2015 Sep 25;290(39):23997-4006. doi: 10.1074/jbc.M115.653378. Epub 
      2015 Aug 12.