PMID- 26269638
OWN - NLM
STAT- MEDLINE
DCOM- 20151105
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 35
IP  - 32
DP  - 2015 Aug 12
TI  - Longitudinal Changes in Prefrontal Cortex Activation Underlie Declines in 
      Adolescent Risk Taking.
PG  - 11308-14
LID - 10.1523/JNEUROSCI.1553-15.2015 [doi]
AB  - Adolescence is a critical developmental phase during which risk-taking behaviors 
      increase across a variety of species, raising the importance of understanding how 
      brain changes contribute to such behaviors. While the prefrontal cortex is 
      thought to influence adolescent risk taking, the specific ways in which it 
      functions are unclear. Using longitudinal functional magnetic resonance imaging 
      in human adolescents, we found that ventrolateral prefrontal cortex (VLPFC) 
      activation decreased during an experimental risk-taking task over time, with 
      greater declines in VLPFC associated with greater declines in self-reported risky 
      behavior. Furthermore, greater decreases in functional coupling between the 
      medial prefrontal cortex (MPFC) and ventral striatum over time were associated 
      with decreases in self-reported risky behavior. Thus, disparate roles of the 
      VLPFC and MPFC modulate longitudinal declines in adolescent risk taking. 
      SIGNIFICANCE STATEMENT: Adolescence is a developmental period marked by steep 
      increases in risk-taking behavior coupled with dramatic brain changes. Although 
      theories propose that the prefrontal cortex (PFC) may influence adolescent risk 
      taking, the specific ways in which it functions remain unclear. We report the 
      first longitudinal functional magnetic resonance imaging study to examine how 
      neural activation during risk taking changes over time and contributes to 
      adolescents' real-life risk-taking behavior. We find that longitudinal declines 
      in activation of the ventrolateral PFC are linked to declines in adolescent risk 
      taking, whereas the medial PFC influences adolescent risk taking via its 
      functional neural coupling with reward-related regions. This is the first study 
      to identify the mechanism by which different regions of the PFC disparately 
      contribute to declines in risk taking.
CI  - Copyright (c) 2015 the authors 0270-6474/15/3511308-07$15.00/0.
FAU - Qu, Yang
AU  - Qu Y
AD  - Department of Psychology, ehtelzer@illinois.edu yangqu3@illinois.edu.
FAU - Galvan, Adriana
AU  - Galvan A
AD  - Department of Psychology, Brain Research Institute.
FAU - Fuligni, Andrew J
AU  - Fuligni AJ
AD  - Department of Psychology, Department of Psychiatry and Biobehavioral Sciences, 
      University of California, Los Angeles, Los Angeles, California 90095.
FAU - Lieberman, Matthew D
AU  - Lieberman MD
AD  - Department of Psychology, Department of Psychiatry and Biobehavioral Sciences, 
      University of California, Los Angeles, Los Angeles, California 90095.
FAU - Telzer, Eva H
AU  - Telzer EH
AD  - Department of Psychology, Beckman Institute for Advanced Science and Technology, 
      University of Illinois, Urbana-Champaign, Illinois 61820, and 
      ehtelzer@illinois.edu yangqu3@illinois.edu.
LA  - eng
GR  - R01 HD057164/HD/NICHD NIH HHS/United States
GR  - R01HD057164/HD/NICHD NIH HHS/United States
GR  - R01HD057164-S/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*physiology
MH  - Brain Mapping
MH  - Decision Making/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prefrontal Cortex/*physiology
MH  - *Reward
MH  - *Risk-Taking
PMC - PMC4532760
OTO - NOTNLM
OT  - adolescence
OT  - fMRI
OT  - prefrontal cortex
OT  - risk taking
EDAT- 2015/08/14 06:00
MHDA- 2015/11/06 06:00
PMCR- 2016/02/12
CRDT- 2015/08/14 06:00
PHST- 2015/08/14 06:00 [entrez]
PHST- 2015/08/14 06:00 [pubmed]
PHST- 2015/11/06 06:00 [medline]
PHST- 2016/02/12 00:00 [pmc-release]
AID - 35/32/11308 [pii]
AID - 1553-15 [pii]
AID - 10.1523/JNEUROSCI.1553-15.2015 [doi]
PST - ppublish
SO  - J Neurosci. 2015 Aug 12;35(32):11308-14. doi: 10.1523/JNEUROSCI.1553-15.2015.