PMID- 26273368
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150814
LR  - 20181113
IS  - 1759-7706 (Print)
IS  - 1759-7714 (Electronic)
IS  - 1759-7706 (Linking)
VI  - 6
IP  - 3
DP  - 2015 May
TI  - Usefulness of target delineation based on the two extreme phases of a 
      four-dimensional computed tomography scan in stereotactic body radiation therapy 
      for lung cancer.
PG  - 239-46
LID - 10.1111/1759-7714.12170 [doi]
AB  - BACKGROUND: An evaluation of the usefulness of target delineation based only on 
      the two extreme phases of a four-dimensional computed tomography (4D CT) scan in 
      lung stereotactic body radiation therapy (SBRT). METHODS: Seventeen patients 
      treated with SBRT via 4D CT scans for lung cancer were retrospectively enrolled. 
      Volumetric and geometric analyses were performed for the internal target volumes 
      (ITVs) and planning target volumes (PTVs) generated using different respiratory 
      phases (all phases and 2 extreme phases) and setup margins (3 mm and 5 mm). 
      RESULTS: As the setup margins were added to the ITVs, the overlap percentage 
      between the PTVs based on all phases and the two extreme phases increased (85.1% 
      for ITVs, 89.8% for PTVs_3 mm, and 91.3% for PTVs_5 mm), and there were no 
      differences according to the tumor parameters, such as the gross tumor volume and 
      3D mobility. The missing-volume differences for ITVs derived from cone-beam CT 
      images also decreased, with values of 5.3% between ITVs, 0.5% between PTVs_3 mm, 
      and 0.2% between PTVs_5 mm. Compared with the plan based on all phases and a 3 mm 
      margin, the average lung-dose differences found for the PTV based on the two 
      extreme phases and a 5 mm margin were 0.41 Gy for the mean lung dose and 0.93% 
      for V20. CONCLUSIONS: Regardless of tumor characteristics, PTV construction based 
      only on the two extreme phases and a 5 mm setup margin may be a useful tool for 
      reducing the clinical workload involved in target delineation in SBRT for lung 
      cancer.
FAU - Jang, Seong Soon
AU  - Jang SS
AD  - Department of Radiation Oncology, College of Medicine, The Catholic University of 
      Korea Seoul, Republic of Korea.
FAU - Huh, Gil Ja
AU  - Huh GJ
AD  - Department of Radiation Oncology, College of Medicine, The Catholic University of 
      Korea Seoul, Republic of Korea.
FAU - Park, Suk Young
AU  - Park SY
AD  - Department of Internal Medicine, College of Medicine, The Catholic University of 
      Korea Seoul, Republic of Korea.
FAU - Yang, Po Song
AU  - Yang PS
AD  - Department of Radiology, College of Medicine, The Catholic University of Korea 
      Seoul, Republic of Korea.
FAU - Cho, EunYoun
AU  - Cho E
AD  - Department of Radiation Oncology, Daejeon St. Mary's Hospital Daejeon, Republic 
      of Korea.
LA  - eng
PT  - Journal Article
DEP - 20150424
PL  - Singapore
TA  - Thorac Cancer
JT  - Thoracic cancer
JID - 101531441
PMC - PMC4448380
OTO - NOTNLM
OT  - 4D CT
OT  - lung cancer
OT  - planning target volume
OT  - stereotactic body radiation therapy
EDAT- 2015/08/15 06:00
MHDA- 2015/08/15 06:01
PMCR- 2015/05/01
CRDT- 2015/08/15 06:00
PHST- 2014/07/09 00:00 [received]
PHST- 2014/08/29 00:00 [accepted]
PHST- 2015/08/15 06:00 [entrez]
PHST- 2015/08/15 06:00 [pubmed]
PHST- 2015/08/15 06:01 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 10.1111/1759-7714.12170 [doi]
PST - ppublish
SO  - Thorac Cancer. 2015 May;6(3):239-46. doi: 10.1111/1759-7714.12170. Epub 2015 Apr 
      24.