PMID- 26273574
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150814
LR  - 20220408
IS  - 2287-3651 (Print)
IS  - 2287-366X (Electronic)
IS  - 2287-3651 (Linking)
VI  - 4
IP  - 2
DP  - 2015 Jul
TI  - Porcine reproductive and respiratory syndrome virus vaccine does not fit in 
      classical vaccinology.
PG  - 159-65
LID - 10.7774/cevr.2015.4.2.159 [doi]
AB  - All vaccines are developed to elicit an effective immune response in vaccinated 
      animals such as innate, humoral and cell mediated response to protect animal 
      health. Quality and intensity of the immune responses are differing by 
      characteristics of the vaccine formulation and nature of the infectious agent. 
      Modified live virus vaccines showed advantages over killed vaccines in terms of 
      rapid immune response, duration of the immunity and better cell mediated 
      protection mechanism. The porcine reproductive and respiratory syndrome virus 
      (PRRSV) is relatively newly emerging (1986 in United States, 1990 in Europe) 
      viral pathogen in pigs and tremendous effort has been made to protect pigs from 
      this economically devastating disease such as developing killed, modified live, 
      recombinant protein based and DNA vaccines. However, only cell culture attenuated 
      virus vaccine is practiced with arguably limited efficacy. The PRRSV vaccine did 
      not clear virus from infected pigs nor prevent re-infection of the virus. The 
      vaccine showed very limited innate immune response, low anamnestic immune 
      response and negligible cell mediated immune response. Despite of the current 
      developed scientific technology, there still remain many questions to solve a 
      most important pig disease worldwide.
FAU - Lyoo, Young S
AU  - Lyoo YS
AD  - Department of Pathology, College of Veterinary Medicine, Konkuk University, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150729
PL  - Korea (South)
TA  - Clin Exp Vaccine Res
JT  - Clinical and experimental vaccine research
JID - 101592344
PMC - PMC4524900
OTO - NOTNLM
OT  - Immunity
OT  - Porcine respiratory and reproductive syndrome virus
OT  - Vaccines
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2015/08/15 06:00
MHDA- 2015/08/15 06:01
PMCR- 2015/07/01
CRDT- 2015/08/15 06:00
PHST- 2015/05/20 00:00 [received]
PHST- 2015/06/18 00:00 [revised]
PHST- 2015/06/25 00:00 [accepted]
PHST- 2015/08/15 06:00 [entrez]
PHST- 2015/08/15 06:00 [pubmed]
PHST- 2015/08/15 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - 10.7774/cevr.2015.4.2.159 [doi]
PST - ppublish
SO  - Clin Exp Vaccine Res. 2015 Jul;4(2):159-65. doi: 10.7774/cevr.2015.4.2.159. Epub 
      2015 Jul 29.