PMID- 26273662
OWN - NLM
STAT- MEDLINE
DCOM- 20160722
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2015
DP  - 2015
TI  - Association of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and 
      Peroxisome Proliferator-Activated Receptors- gamma 2 with Type 2 Diabetes Mellitus 
      and is Interaction with Obesity Status in Emirati Population.
PG  - 129695
LID - 10.1155/2015/129695 [doi]
LID - 129695
AB  - BACKGROUND: Transcription factor 7-like 2 gene (TCF7L2) and peroxisome 
      proliferator-activated receptors-gamma2 (PPAR-gamma2) have a profound effect on the 
      incidence of type 2 diabetes mellitus (T2DM) and had previously been found to be 
      associated with T2DM risk in various ppopulations. However, studies in the Arab 
      population are inconsistent. We conducted a case control study to confirm the 
      association of variants rs10885409 of TCF7L2 and Pro12Ala (rs1801282) of PPAR-gamma2 
      with risk of T2DM and related complications in Emirati population of Arab origin. 
      We also investigated the interaction of these associations with obesity status. 
      METHODS: DNA was extracted from the saliva samples of 272 T2DM patients and 216 
      nondiabetic Emiratis. Genotyping for rs10885409 (TCF7L2) and rs1801282 (PPAR-gamma2 
      P12A) variants was accomplished with a TaqMan assay. The subgroups were 
      constituted according to obesity status. RESULTS: In the nonobese group, the 
      rs10885409 C allele in the recessive model was significantly associated with the 
      incidence of T2DM (OR 1.975 [95% CI 1.127-3.461], P = 0.017), but this 
      association was not observed in the obese group or when BMI was not considered. 
      PPAR-gamma2 risk allele Pro12 frequency (0.96) was similar in the groups tested and 
      more than 90% population was homozygous for this allele. CONCLUSIONS: Our 
      case-control study is the first of its kind in Emiratis which establishes TCF7L2 
      rs10885409 C allele as a T2DM risk factor in Emiratis and this association is 
      modulated by obesity status. We also confirmed that Pro12Ala mutation in PPAR-gamma2 
      is not associated with T2DM risk in this population.
FAU - Al-Safar, Habiba
AU  - Al-Safar H
AD  - Department of Biomedical Engineering, Khalifa University of Science, Technology & 
      Research, P.O. Box 127788, Abu Dhabi, UAE.
FAU - Hassoun, Ahmed
AU  - Hassoun A
AD  - Dubai Diabetes Centre, Dubai Health Authority, Dubai, UAE.
FAU - Almazrouei, Shaikha
AU  - Almazrouei S
AD  - Department of Biomedical Engineering, Khalifa University of Science, Technology & 
      Research, P.O. Box 127788, Abu Dhabi, UAE.
FAU - Kamal, Wala
AU  - Kamal W
AD  - School of Life Sciences, Manipal University, P.O. Box 345050, Dubai, UAE.
FAU - Afandi, Bachar
AU  - Afandi B
AD  - Diabetes Clinics, Tawam Hospital, Al-Ain, UAE.
FAU - Rais, Naushad
AU  - Rais N
AD  - School of Life Sciences, Manipal University, P.O. Box 345050, Dubai, UAE.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150727
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (PPAR gamma)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Diabetes Complications/blood/ethnology/genetics
MH  - Diabetes Mellitus, Type 2/*blood/ethnology/*genetics
MH  - Female
MH  - Genes, Recessive
MH  - Genetic Variation
MH  - Genotype
MH  - Healthy Volunteers
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Obesity/*blood/ethnology/*genetics
MH  - PPAR gamma/*metabolism
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Sequence Analysis, DNA
MH  - Transcription Factor 7-Like 2 Protein/*genetics
MH  - United Arab Emirates
PMC - PMC4530252
EDAT- 2015/08/15 06:00
MHDA- 2016/07/23 06:00
PMCR- 2015/07/27
CRDT- 2015/08/15 06:00
PHST- 2014/10/14 00:00 [received]
PHST- 2015/04/27 00:00 [revised]
PHST- 2015/04/27 00:00 [accepted]
PHST- 2015/08/15 06:00 [entrez]
PHST- 2015/08/15 06:00 [pubmed]
PHST- 2016/07/23 06:00 [medline]
PHST- 2015/07/27 00:00 [pmc-release]
AID - 10.1155/2015/129695 [doi]
PST - ppublish
SO  - J Diabetes Res. 2015;2015:129695. doi: 10.1155/2015/129695. Epub 2015 Jul 27.