PMID- 26275186
OWN - NLM
STAT- MEDLINE
DCOM- 20170215
LR  - 20171116
IS  - 1998-3603 (Electronic)
IS  - 0970-9290 (Linking)
VI  - 26
IP  - 3
DP  - 2015 May-Jun
TI  - Role of cardiovascular disease markers in periodontal infection: Understanding 
      the risk.
PG  - 231-6
LID - 10.4103/0970-9290.162873 [doi]
AB  - CONTEXT: Both periodontitis and cardiovascular diseases (CVD) represent chronic 
      inflammatory conditions, and periodontal infections have been postulated to 
      perpetuate the progression of CVD's. However, limited evidence is available to 
      prove the causal relationship. AIM: An effort in exploring this interrelation has 
      been made in this study. The role of two inflammatory mediators, soluble CD40 
      ligand (sCD40 L) and monocyte chemoattractant protein-1 (MCP-1) has been 
      established in progression and acute precipitation of CVD's. Due to a close link 
      between these two mediators, the present study was designed to correlate the 
      levels of sCD40 L and MCP-1 in serum and gingival crevicular fluid (GCF) of 
      patients with chronic periodontitis. METHODS: Fifteen healthy and 30 patients of 
      severe chronic periodontitis (diseased) participated in the study. Patients of 
      the diseased group underwent scaling/root planning. The evaluation of plaque 
      index, gingival index, probing depth, clinical attachment level, and a collection 
      of serum and GCF samples was done at baseline and 6 weeks following periodontal 
      therapy. The sCD40 L and MCP-1 levels were quantified using ELISA. RESULTS: The 
      sCD40 L levels correlated strongly with MCP-1 levels in both GCF (r = 0.888) and 
      serum (r = 0.861) in patients of chronic periodontitis. The relationship between 
      the levels of the two markers was maintained in GCF (r = 0.868) and serum (r = 
      0.750) after Phase I periodontal therapy. CONCLUSIONS: The positive correlation 
      observed suggests this pathway as one of the mechanisms that may lead to 
      increasing severity of periodontal disease and its systemic effects. Further 
      research efforts should be made in designing appropriate clinical trials, 
      starting at an early stage and monitoring the potential benefits of maintenance 
      of oral hygiene on cardiovascular health.
FAU - Gupta, Mili
AU  - Gupta M
FAU - Chaturvedi, Rashi
AU  - Chaturvedi R
AD  - Department of Periodontics, Dr. Harvansh Singh Judge Institute of Dental Sciences 
      and Hospital, Panjab University, Chandigarh, India.
FAU - Jain, Ashish
AU  - Jain A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Dent Res
JT  - Indian journal of dental research : official publication of Indian Society for 
      Dental Research
JID - 9202990
RN  - 0 (CD40 Antigens)
MH  - CD40 Antigens/*metabolism
MH  - Cardiovascular Diseases/*metabolism
MH  - Chronic Periodontitis/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Risk Factors
EDAT- 2015/08/15 06:00
MHDA- 2017/02/16 06:00
CRDT- 2015/08/15 06:00
PHST- 2015/08/15 06:00 [entrez]
PHST- 2015/08/15 06:00 [pubmed]
PHST- 2017/02/16 06:00 [medline]
AID - IndianJDentRes_2015_26_3_231_162873 [pii]
AID - 10.4103/0970-9290.162873 [doi]
PST - ppublish
SO  - Indian J Dent Res. 2015 May-Jun;26(3):231-6. doi: 10.4103/0970-9290.162873.