PMID- 26275199
OWN - NLM
STAT- MEDLINE
DCOM- 20170215
LR  - 20171116
IS  - 1998-3603 (Electronic)
IS  - 0970-9290 (Linking)
VI  - 26
IP  - 3
DP  - 2015 May-Jun
TI  - Expression of CD 68, CD 45 and human leukocyte antigen-DR in central and 
      peripheral giant cell granuloma, giant cell tumor of long bones, and tuberculous 
      granuloma: An immunohistochemical study.
PG  - 295-303
LID - 10.4103/0970-9290.162872 [doi]
AB  - BACKGROUND: Multinucleated giant cells (MNCs) form an integral part of numerous 
      bone and soft tissue tumors, tumor-like lesions and are often associated with 
      granulomas of immunological and nonimmunological origin. The presence of various 
      types of giant cells depends on the lesions in which they are present which are 
      difficult to be diagnosed under routine histological techniques. 
      Immunohistochemistry can be used for a better diagnosis and understanding of the 
      origin of various giant cells using various markers of immune response like human 
      leukocyte antigen-DR (HLA-DR) and those expressed on monocytes and macrophages 
      like CD 68 and leukocyte common antigen (LCA). MATERIALS AND METHODS: The study 
      group consisted of 10 cases of giant cell tumor (GCT) of long bones, tuberculous 
      granuloma, and giant cell granuloma to evaluate and analyze the expression 
      pattern of LCA, CD 68, and HLA-DR in various giant cell lesions. RESULTS: Strong 
      expression of CD 68 was observed in 80% of the lesions, strong and moderate 
      expression of CD 45 observed in 70% of the lesions among and within the groups. 
      In contrast, HLA-DR demonstrated negative expression in 80% of cases except for 
      tuberculous granuloma where all the 10 cases showed moderate to strong 
      immunoreactivity. CONCLUSION: CD 68 and CD 45 expression was found in central 
      giant cell granuloma, peripheral giant cell granuloma and GCT, suggesting the 
      origin from mononuclear phagocyte system and considering their clinical behavior 
      of osteoclast type. High expressivity of HLA-DR in tuberculous granulomas which 
      is an essential factor for presentation of the microbial antigen to CD 4 helper 
      cells thus reassuring the fact that they are up-regulated in response to 
      infection.
FAU - Kumar, Anoop
AU  - Kumar A
FAU - Sherlin, Herald J
AU  - Sherlin HJ
AD  - Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Chennai, 
      Tamil Nadu, India.
FAU - Ramani, Pratibha
AU  - Ramani P
FAU - Natesan, Anuja
AU  - Natesan A
FAU - Premkumar, Priya
AU  - Premkumar P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Dent Res
JT  - Indian journal of dental research : official publication of Indian Society for 
      Dental Research
JID - 9202990
RN  - 0 (HLA Antigens)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
MH  - Bone Neoplasms/*immunology
MH  - Giant Cell Tumors/*immunology/pathology
MH  - Granuloma, Giant Cell/*immunology/pathology
MH  - HLA Antigens/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Leukocyte Common Antigens/*immunology
MH  - Macrophages/pathology
EDAT- 2015/08/15 06:00
MHDA- 2017/02/16 06:00
CRDT- 2015/08/15 06:00
PHST- 2015/08/15 06:00 [entrez]
PHST- 2015/08/15 06:00 [pubmed]
PHST- 2017/02/16 06:00 [medline]
AID - IndianJDentRes_2015_26_3_295_162872 [pii]
AID - 10.4103/0970-9290.162872 [doi]
PST - ppublish
SO  - Indian J Dent Res. 2015 May-Jun;26(3):295-303. doi: 10.4103/0970-9290.162872.