PMID- 26276042
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20220317
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 31
IP  - 4
DP  - 2015 Oct
TI  - White tea consumption restores sperm quality in prediabetic rats preventing 
      testicular oxidative damage.
PG  - 544-56
LID - S1472-6483(15)00357-0 [pii]
LID - 10.1016/j.rbmo.2015.06.021 [doi]
AB  - Prediabetes represents a major risk factor for the development of type 2 diabetes 
      mellitus (T2DM). It encompasses some, but not all, T2DM diagnostic criteria. 
      Prediabetes has been recently associated with altered testicular function and 
      increased testicular oxidative stress (OS). Tea is widely consumed and its 
      anti-hyperglycaemic/antioxidant properties are known. This study aimed to 
      evaluate whether white tea (WTEA) consumption by prediabetic rats could prevent 
      testicular OS, preserving sperm quality. For that purpose, WTEA (presenting a 
      high catechin content) was given to 30-day-old streptozotocin-induced prediabetic 
      rats for 2 months. Testicular antioxidant potential and OS were evaluated, as 
      well as sperm parameters, by standard techniques. WTEA consumption improved 
      glucose tolerance and insulin sensitivity in prediabetic rats. Testicular 
      antioxidant potential was increased by WTEA consumption, restoring protein 
      oxidation and lipid peroxidation, although glutathione content and redox state 
      were not altered. WTEA consumption improved sperm concentration and sperm quality 
      (motility, viability and abnormality) was restored. Overall, WTEA consumption 
      improved reproductive health of male prediabetic rats. Based on the study 
      results, WTEA consumption appears to be a natural, economical and effective 
      strategy to counteract the deleterious effects of prediabetes on male 
      reproductive health, but further studies will be needed before a definitive 
      recommendation is made.
CI  - Copyright (c) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Oliveira, Pedro F
AU  - Oliveira PF
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal; Department of Microscopy, Laboratory of Cell Biology, 
      Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for 
      Multidisciplinary Investigation in Biomedicine (UMIB), University of Porto, 
      Portugal. Electronic address: pfobox@gmail.com.
FAU - Tomas, Goncalo D
AU  - Tomas GD
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal.
FAU - Dias, Tania R
AU  - Dias TR
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal.
FAU - Martins, Ana D
AU  - Martins AD
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal; Department of Microscopy, Laboratory of Cell Biology, 
      Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for 
      Multidisciplinary Investigation in Biomedicine (UMIB), University of Porto, 
      Portugal.
FAU - Rato, Luis
AU  - Rato L
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal.
FAU - Alves, Marco G
AU  - Alves MG
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal.
FAU - Silva, Branca M
AU  - Silva BM
AD  - CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 
      6201-506 Covilha, Portugal. Electronic address: bmcms@ubi.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150714
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (Phytochemicals)
RN  - 0 (Tea)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Diabetes Complications/diet therapy/etiology/pathology
MH  - Diabetes Mellitus, Experimental/diet therapy/pathology/physiopathology
MH  - Glucose Tolerance Test
MH  - Glutathione/metabolism
MH  - Infertility, Male/diet therapy/etiology/pathology
MH  - Insulin Resistance
MH  - Lipid Peroxidation
MH  - Male
MH  - *Oxidative Stress
MH  - Phytochemicals/chemistry
MH  - Prediabetic State/*diet therapy/pathology/physiopathology
MH  - Protein Carbonylation
MH  - Rats
MH  - Rats, Wistar
MH  - *Semen Analysis
MH  - Sperm Count
MH  - Sperm Motility
MH  - Spermatozoa/abnormalities
MH  - *Tea/chemistry
MH  - Testis/*metabolism
OTO - NOTNLM
OT  - diabetes mellitus
OT  - male fertility
OT  - oxidative stress
OT  - sperm quality
OT  - white tea
EDAT- 2015/08/16 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/08/16 06:00
PHST- 2014/12/22 00:00 [received]
PHST- 2015/06/16 00:00 [revised]
PHST- 2015/06/23 00:00 [accepted]
PHST- 2015/08/16 06:00 [entrez]
PHST- 2015/08/16 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - S1472-6483(15)00357-0 [pii]
AID - 10.1016/j.rbmo.2015.06.021 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2015 Oct;31(4):544-56. doi: 10.1016/j.rbmo.2015.06.021. 
      Epub 2015 Jul 14.