PMID- 26276257
OWN - NLM
STAT- MEDLINE
DCOM- 20160906
LR  - 20150924
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 494
IP  - 1
DP  - 2015 Oct 15
TI  - Biomimetic estimation of glucose using non-molecular and molecular imprinted 
      polymer nanosponges.
PG  - 244-8
LID - S0378-5173(15)30119-8 [pii]
LID - 10.1016/j.ijpharm.2015.08.022 [doi]
AB  - The aim of the present work was to develop biomimetics for glucose estimation 
      using molecularly and non-molecularly imprinted polymers of pyromellitic 
      dianhydride crosslinked beta-cyclodextrin based nanosponges. The ionic association 
      of glucose phosphate to nanosponges by polymerization reaction and removal of 
      glucose created molecular imprinted polymer (MIP)-nanosponges with affinity for 
      glucose binding. Particle size, zeta potential, glucose binding studies and FTIR 
      were used to characterize molecular and non-molecular imprinted polymer (NIP) 
      nanosponges. Particle size of the nanosponges was found in the range of 
      450.81+/-5.33 nm to 550.63+/-8.14 nm with low polydispersity index. MIP-nanosponges 
      retained a relatively large population of pores in the nano-range, while NIP was 
      related to the nonporous materials with weak interaction and had poor tendency to 
      aggregate. Nanosponges showed the variation in binding capacities and 
      specificities; and also exhibited a similar degree of swelling. Moreover 
      electrostatic force of attraction and cavities specific fitting of glucose in 
      MIP-nanosponges might be due to advance selectivity and affinity for glucose. 
      FTIR study showed glucose molecules might be entered into the selective binding 
      cavities, which were created by the extraction of template molecules It is 
      concluded that nanosized MIP-nanosponges have advantages over conventional NIP 
      due to diffusion of template in the formed cavity as of its high surface area.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Deshmukh, Kiran
AU  - Deshmukh K
AD  - Department of Science and Technology of Pharmaceutics, University of Torino, 
      Torino, Italy; Faculty of Pharmaceutical Sciences, Jodhpur National University, 
      Jodhpur, Rajasthan, India. Electronic address: kirandeshmukh8@gmail.com.
FAU - Tanwar, Yuveraj Singh
AU  - Tanwar YS
AD  - Bhupal Nobles' College of Pharmacy, Udaipur, Rajasthan, India.
FAU - Shende, Pravin
AU  - Shende P
AD  - Department of Chemistry, University of Torino, Torino, Italy.
FAU - Cavalli, Roberta
AU  - Cavalli R
AD  - Department of Science and Technology of Pharmaceutics, University of Torino, 
      Torino, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150812
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Polymers)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Biomimetics
MH  - Glucose/*chemistry
MH  - *Molecular Imprinting
MH  - Nanostructures/*chemistry
MH  - Particle Size
MH  - Polymerization
MH  - Polymers/chemistry
MH  - Porifera/*chemistry
MH  - Surface Properties
OTO - NOTNLM
OT  - Cyclodextrin
OT  - Glucose
OT  - Molecular-imprinted polymer
OT  - Nanosponges
EDAT- 2015/08/16 06:00
MHDA- 2016/09/07 06:00
CRDT- 2015/08/16 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/08/04 00:00 [revised]
PHST- 2015/08/08 00:00 [accepted]
PHST- 2015/08/16 06:00 [entrez]
PHST- 2015/08/16 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - S0378-5173(15)30119-8 [pii]
AID - 10.1016/j.ijpharm.2015.08.022 [doi]
PST - ppublish
SO  - Int J Pharm. 2015 Oct 15;494(1):244-8. doi: 10.1016/j.ijpharm.2015.08.022. Epub 
      2015 Aug 12.