PMID- 26276782
OWN - NLM
STAT- MEDLINE
DCOM- 20151113
LR  - 20181202
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 144
IP  - 3
DP  - 2015 Sep
TI  - Polypoid laryngeal inflammatory myofibroblastic tumors: misleading lesions: 
      description of six cases showing ALK overexpression.
PG  - 511-6
LID - 10.1309/AJCPCG8D6JAQBVLG [doi]
AB  - OBJECTIVES: Laryngeal inflammatory myofibroblastic tumors (IMTs) are rarely 
      reported in the literature but may be underrecognized. To better characterize 
      their features, we report a series of six cases. METHODS: The clinicopathologic 
      findings, including immunohistochemistry, fluorescence in situ hybridization 
      (FISH) analysis, and follow-up, were evaluated and a review of the literature was 
      performed. RESULTS: These cases presented as small polypoid vocal cord or 
      ventricular band lesions, with a more advanced mean age at diagnosis (49 years) 
      than typically reported in other localizations. Apart from one secondary revision 
      surgery, no complementary treatment and no recurrences were observed. 
      Histologically, various morphologic features were seen. All tumors were spindle 
      cell proliferations on a myxoid background with more or less atypia and 
      significant inflammatory infiltrate. All six cases showed anaplastic lymphoma 
      kinase (ALK) immunohistochemical expression. FISH rearrangement was present in 
      four of six cases. Only two cases were initially diagnosed as IMT. CONCLUSIONS: 
      According to our series, laryngeal IMTs are easily misdiagnosed. They have a good 
      prognosis, and ALK immunohistochemistry should be carried out to assess this 
      diagnosis when spindle cell proliferations are observed in this localization.
CI  - Copyright(c) by the American Society for Clinical Pathology.
FAU - Pierry, Clemence
AU  - Pierry C
AD  - From the Department of Biopathology, Institut Bergonie, Bordeaux, France;
FAU - Perot, Gaelle
AU  - Perot G
AD  - From the Department of Biopathology, Institut Bergonie, Bordeaux, France;
FAU - Karanian-Philippe, Marie
AU  - Karanian-Philippe M
AD  - From the Department of Biopathology, Institut Bergonie, Bordeaux, France; 
      Universite Bordeaux, Bordeaux, France;
FAU - Neuville, Agnes
AU  - Neuville A
AD  - From the Department of Biopathology, Institut Bergonie, Bordeaux, France; 
      Universite Bordeaux, Bordeaux, France;
FAU - Gomez-Brouchet, Anne
AU  - Gomez-Brouchet A
AD  - Department of Pathology, Rangueil University Hospital, Toulouse, France; and.
FAU - Crestani, Sabine
AU  - Crestani S
AD  - ENT and Maxillofacial Surgery Department, Larrey University Hospital, Toulouse, 
      France.
FAU - Coindre, Jean-Michel
AU  - Coindre JM
AD  - From the Department of Biopathology, Institut Bergonie, Bordeaux, France; 
      Universite Bordeaux, Bordeaux, France; j.coindre@bordeaux.unicancer.fr.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Anaplastic Lymphoma Kinase
MH  - Biomarkers, Tumor/*metabolism
MH  - Diagnostic Errors/prevention & control
MH  - Female
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Laryngeal Neoplasms/*diagnosis/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Muscle Tissue/*diagnosis/*metabolism
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
OTO - NOTNLM
OT  - ALK
OT  - Anaplastic lymphoma kinase
OT  - Inflammatory myofibroblastic tumor
OT  - Laryngeal tumor
OT  - Vocal cord polyp
EDAT- 2015/08/16 06:00
MHDA- 2015/11/14 06:00
CRDT- 2015/08/16 06:00
PHST- 2015/08/16 06:00 [entrez]
PHST- 2015/08/16 06:00 [pubmed]
PHST- 2015/11/14 06:00 [medline]
AID - 144/3/511 [pii]
AID - 10.1309/AJCPCG8D6JAQBVLG [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2015 Sep;144(3):511-6. doi: 10.1309/AJCPCG8D6JAQBVLG.