PMID- 26277543
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20220331
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 43
DP  - 2015 Jul
TI  - MYC and metabolism on the path to cancer.
PG  - 11-21
LID - S1084-9521(15)00147-0 [pii]
LID - 10.1016/j.semcdb.2015.08.003 [doi]
AB  - The MYC proto-oncogene is frequently deregulated in human cancers, activating 
      genetic programs that orchestrate biological processes to promote growth and 
      proliferation. Altered metabolism characterized by heightened nutrients uptake, 
      enhanced glycolysis and glutaminolysis and elevated fatty acid and nucleotide 
      synthesis is the hallmark of MYC-driven cancer. Recent evidence strongly suggests 
      that Myc-dependent metabolic reprogramming is critical for tumorigenesis, which 
      could be attenuated by targeting specific metabolic pathways using small 
      drug-like molecules. Understanding the complexity of MYC-mediated metabolic 
      re-wiring in cancers as well as how MYC cooperates with other metabolic drivers 
      such as mammalian target of rapamycin (mTOR) will provide translational 
      opportunities for cancer therapy.
CI  - Copyright (c) 2015. Published by Elsevier Ltd.
FAU - Hsieh, Annie L
AU  - Hsieh AL
AD  - Abramson Family Cancer Research Institute, Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, 
      Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 
      Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, 
      MD, USA.
FAU - Walton, Zandra E
AU  - Walton ZE
AD  - Abramson Family Cancer Research Institute, Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, 
      Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Altman, Brian J
AU  - Altman BJ
AD  - Abramson Family Cancer Research Institute, Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, 
      Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Stine, Zachary E
AU  - Stine ZE
AD  - Abramson Family Cancer Research Institute, Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, 
      Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Dang, Chi V
AU  - Dang CV
AD  - Abramson Family Cancer Research Institute, Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, 
      Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 
      Division of Hematology-Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: 
      dangvchi@exchange.upenn.edu.
LA  - eng
GR  - R01 CA057341/CA/NCI NIH HHS/United States
GR  - F32 CA174148/CA/NCI NIH HHS/United States
GR  - T32 CA009140/CA/NCI NIH HHS/United States
GR  - R01 CA051497/CA/NCI NIH HHS/United States
GR  - P30 CA016520/CA/NCI NIH HHS/United States
GR  - #R01CA057341/CA/NCI NIH HHS/United States
GR  - F32 CA180370/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150812
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (MAS1 protein, human)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Cell Proliferation/physiology
MH  - Cell Transformation, Neoplastic/*pathology
MH  - Glucose/*metabolism
MH  - Glycolysis/*physiology
MH  - Homeostasis/*physiology
MH  - Humans
MH  - Neoplasms/*pathology
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-myc/genetics/*metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Transcriptional Activation/genetics
PMC - PMC4818970
MID - NIHMS719250
OTO - NOTNLM
OT  - Cancer
OT  - Metabolism
OT  - Myc
OT  - mTOR
EDAT- 2015/08/19 06:00
MHDA- 2016/09/27 06:00
PMCR- 2016/04/03
CRDT- 2015/08/17 06:00
PHST- 2015/05/08 00:00 [received]
PHST- 2015/07/17 00:00 [revised]
PHST- 2015/08/09 00:00 [accepted]
PHST- 2015/08/17 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
PHST- 2016/04/03 00:00 [pmc-release]
AID - S1084-9521(15)00147-0 [pii]
AID - 10.1016/j.semcdb.2015.08.003 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2015 Jul;43:11-21. doi: 10.1016/j.semcdb.2015.08.003. Epub 
      2015 Aug 12.