PMID- 26277904
OWN - NLM
STAT- MEDLINE
DCOM- 20160629
LR  - 20211203
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 84
IP  - 3
DP  - 2015
TI  - Health-Related Quality of Life in Children with Congenital Adrenal Hyperplasia.
PG  - 165-71
LID - 10.1159/000435855 [doi]
AB  - BACKGROUND/AIMS: Factors in congenital adrenal hyperplasia (CAH) that may affect 
      quality of life (QOL) include the need for lifelong medication, the risk of 
      adrenal crisis, and hyperandrogenic symptoms. The objectives were to evaluate 
      health-related QOL (HRQOL) in children with CAH, and whether CAH poses an 
      additional burden compared to other endocrine disorders. METHODS: The validated 
      PedsQL 4.0 generic core scales were administered to subjects (8-18 years) with 
      CAH and hypothyroidism and their parents. The minimal clinically important 
      difference (MCID) was determined for each scale score, allowing a comparison with 
      the healthy population. A score of >1 standard deviation below the population 
      mean was considered at risk for impaired HRQOL. RESULTS: In CAH, the mean total 
      HRQOL scores were >1 MCID below the population mean, and a higher percentage than 
      expected had scores considered at risk. CONCLUSION: Compared to subjects with 
      hypothyroidism, subjects with CAH self-reported lower school domain scores. CAH 
      subjects more frequently reported peers not wanting to be friends.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Yau, Mabel
AU  - Yau M
AD  - Department of Pediatric Endocrinology, Icahn School of Medicine at Mount Sinai, 
      New York, N.Y., USA.
FAU - Vogiatzi, Maria
AU  - Vogiatzi M
FAU - Lewkowitz-Shpuntoff, Ariana
AU  - Lewkowitz-Shpuntoff A
FAU - Nimkarn, Saroj
AU  - Nimkarn S
FAU - Lin-Su, Karen
AU  - Lin-Su K
LA  - eng
PT  - Journal Article
DEP - 20150801
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
SB  - IM
MH  - Adolescent
MH  - Adrenal Hyperplasia, Congenital/*psychology
MH  - Child
MH  - Emotions
MH  - Ethnicity
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Parents
MH  - Peer Group
MH  - *Quality of Life
MH  - Schools
MH  - Social Behavior
EDAT- 2015/08/19 06:00
MHDA- 2016/06/30 06:00
CRDT- 2015/08/18 06:00
PHST- 2015/02/03 00:00 [received]
PHST- 2015/06/09 00:00 [accepted]
PHST- 2015/08/18 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/06/30 06:00 [medline]
AID - 000435855 [pii]
AID - 10.1159/000435855 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2015;84(3):165-71. doi: 10.1159/000435855. Epub 2015 Aug 1.