PMID- 2627799
OWN - NLM
STAT- MEDLINE
DCOM- 19900425
LR  - 20190828
IS  - 0271-3683 (Print)
IS  - 0271-3683 (Linking)
VI  - 8
IP  - 12
DP  - 1989 Dec
TI  - Intramuscular injection of chlorpromazine decreases intraocular pressure by 
      lowering systemic blood pressure.
PG  - 1315-21
AB  - Intramuscular injection of chlorpromazine in rabbits caused a significant 
      decrease in intraocular pressure (IOP). The dose-response curve was generated. 
      The threshold dose was 0.1 mg/kg (approximately 0.35 mg per rabbit) and 10 mg/kg 
      chlorpromazine produced the maximal response which lasted for several hours. This 
      decrease in IOP was not due to the release of pituitary prolactin by a central 
      dopaminergic-2 antagonistic activity of chlorpromazine. Intracerebroventricular 
      (i.c.v.) injection of chlorpromazine also caused a decrease in IOP. The threshold 
      dose was 0.33 mg per rabbit. This high i.c.v. threshold dose indicates that no 
      direct central mechanism is responsible for the decrease of IOP after an i.m. 
      injection of chlorpromazine. Intravitreal injection of 0.35 mg chlorpromazine 
      caused significant miosis without any change in IOP. It appears that direct 
      mechanisms of chlorpromazine in ocular tissues do not decrease IOP. After an i.m. 
      injection of 0.1 or 10 mg/kg chlorpromazine, systemic blood pressure (BP) was 
      lowered in a similar pattern as the decrease in IOP. Neither IOP nor BP was 
      affected by an i.m. injection of a subthreshold chlorpromazine dose of 0.01 
      mg/kg. These observations suggest that the decrease in IOP after an i.m. 
      injection of chlorpromazine is mainly due to the decrease of BP.
FAU - Liu, J H
AU  - Liu JH
AD  - Eye Research Institute, Retina Foundation, Boston, MA 02114.
FAU - Dacus, A C
AU  - Dacus AC
LA  - eng
GR  - EY-07544/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 9002-62-4 (Prolactin)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Central Nervous System/drug effects/physiology
MH  - Chlorpromazine/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heart Rate/drug effects
MH  - Injections, Intramuscular
MH  - Injections, Intraventricular
MH  - Intraocular Pressure/*drug effects
MH  - Male
MH  - Prolactin/blood
MH  - Pupil/drug effects
MH  - Rabbits
MH  - Vitreous Body/drug effects
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
AID - 10.3109/02713688909013912 [doi]
PST - ppublish
SO  - Curr Eye Res. 1989 Dec;8(12):1315-21. doi: 10.3109/02713688909013912.