PMID- 26277996
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20220311
IS  - 1421-9913 (Electronic)
IS  - 0014-3022 (Linking)
VI  - 74
IP  - 1-2
DP  - 2015
TI  - Anti-NMDAR Encephalitis of 11 Cases in China - Detailed Clinical, Laboratory and 
      Imagiological Description.
PG  - 73-8
LID - 10.1159/000435953 [doi]
AB  - BACKGROUND AND PURPOSE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis 
      is a synaptic autoimmune disorder in which the auto-antibodies target NMDARs were 
      first reported in 2007. Now, anti-NMDAR encephalitis is a widely recognized 
      disease in the world. Our purpose was to analyze the clinical characteristics of 
      anti-NMDAR encephalitis patients in West China Hospital in China and report the 
      prognosis of the patients after accepting immunotherapy. METHODS: Patients 
      admitted to the West China Hospital who were diagnosed with anti-NMDAR 
      encephalitis from 2013 to 2014 were retrospectively collected and their clinical 
      features were analyzed. RESULTS: We ultimately included 11 anti-NMDAR 
      encephalitis patients. The median age of the 11 patients was 25 years, 46% 
      patients were females, 27% patients were 15-18 years, and 73% patients were over 
      18 years. One of them was diagnosed with teratoma after discharging from 
      hospital. The application of immunotherapy produced favorable outcomes in 67% 
      patients included in our study. CONCLUSIONS: Anti-NMDAR encephalitis should be 
      suspected in patients who developed a rapid change in behavior or psychosis, 
      seizures, dyskinesia, and hypoventilation. Anti-NMDAR encephalitis is a kind of 
      fatal but treatable disease. Timely diagnosis and treatment may yield favorable 
      prognosis.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Liu, Junfeng
AU  - Liu J
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Wang, Deren
AU  - Wang D
FAU - Xiong, Yao
AU  - Xiong Y
FAU - Liu, Bian
AU  - Liu B
FAU - Liu, Ming
AU  - Liu M
LA  - eng
PT  - Journal Article
DEP - 20150808
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*diagnosis/immunology/therapy
MH  - China
MH  - Female
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Receptors, N-Methyl-D-Aspartate/immunology
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2015/08/19 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/08/18 06:00
PHST- 2015/02/16 00:00 [received]
PHST- 2015/06/14 00:00 [accepted]
PHST- 2015/08/18 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 000435953 [pii]
AID - 10.1159/000435953 [doi]
PST - ppublish
SO  - Eur Neurol. 2015;74(1-2):73-8. doi: 10.1159/000435953. Epub 2015 Aug 8.