PMID- 26279572
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20210829
IS  - 2211-1247 (Electronic)
VI  - 12
IP  - 8
DP  - 2015 Aug 25
TI  - Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 
      Responses.
PG  - 1314-24
LID - S2211-1247(15)00800-1 [pii]
LID - 10.1016/j.celrep.2015.07.040 [doi]
AB  - Generation of different CD4 T cell responses to commensal and pathogenic bacteria 
      is crucial for maintaining a healthy gut environment, but the associated cellular 
      mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) 
      integrate microbial signals and direct adaptive immunity. Although the role of 
      DCs in initiating T cell responses is well appreciated, how Mfs contribute to the 
      generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells 
      are critical for mucosal immune protection and at steady state are induced by 
      commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we 
      examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We 
      show that Mfs, and not conventional CD103(+) DCs, are essential for the 
      generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell 
      responses to certain commensal bacteria.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Panea, Casandra
AU  - Panea C
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Farkas, Adam M
AU  - Farkas AM
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Goto, Yoshiyuki
AU  - Goto Y
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Abdollahi-Roodsaz, Shahla
AU  - Abdollahi-Roodsaz S
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Lee, Carolyn
AU  - Lee C
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Koscso, Balazs
AU  - Koscso B
AD  - Department of Microbiology and Immunology, College of Medicine and Milton S. 
      Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.
FAU - Gowda, Kavitha
AU  - Gowda K
AD  - Department of Microbiology and Immunology, College of Medicine and Milton S. 
      Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.
FAU - Hohl, Tobias M
AU  - Hohl TM
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, NY 10065, USA.
FAU - Bogunovic, Milena
AU  - Bogunovic M
AD  - Department of Microbiology and Immunology, College of Medicine and Milton S. 
      Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.
FAU - Ivanov, Ivaylo I
AU  - Ivanov II
AD  - Department of Microbiology and Immunology, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA. Electronic address: 
      ii2137@cumc.columbia.edu.
LA  - eng
GR  - R37 AI093808/AI/NIAID NIH HHS/United States
GR  - R01-AI093808/AI/NIAID NIH HHS/United States
GR  - R01-DK098378/DK/NIDDK NIH HHS/United States
GR  - R01 AI093808/AI/NIAID NIH HHS/United States
GR  - R01 DK098378/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150813
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Antigens, CD)
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Cx3cr1 protein, mouse)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics/metabolism
MH  - CX3C Chemokine Receptor 1
MH  - Cells, Cultured
MH  - Dendritic Cells/immunology
MH  - Integrin alpha Chains/genetics/metabolism
MH  - Intestinal Mucosa/*immunology/microbiology
MH  - Macrophages/*immunology
MH  - Mice
MH  - Microbiota/*immunology
MH  - Receptors, Chemokine/genetics/metabolism
MH  - Th17 Cells/*immunology
PMC - PMC4567384
MID - NIHMS710550
EDAT- 2015/08/19 06:00
MHDA- 2016/06/18 06:00
PMCR- 2016/08/25
CRDT- 2015/08/18 06:00
PHST- 2014/12/30 00:00 [received]
PHST- 2015/06/11 00:00 [revised]
PHST- 2015/07/16 00:00 [accepted]
PHST- 2015/08/18 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
PHST- 2016/08/25 00:00 [pmc-release]
AID - S2211-1247(15)00800-1 [pii]
AID - 10.1016/j.celrep.2015.07.040 [doi]
PST - ppublish
SO  - Cell Rep. 2015 Aug 25;12(8):1314-24. doi: 10.1016/j.celrep.2015.07.040. Epub 2015 
      Aug 13.