PMID- 26281203
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20190221
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 87
IP  - 6
DP  - 2015
TI  - [The concurrence of light-chain deposition disease, AL-amyloidosis, and cast 
      nephropathy in a patient with multiple myeloma].
PG  - 98-101
LID - 10.17116/terarkh201587698-101 [doi]
AB  - Despite of the fact that their clinical manifestations are similar, 
      AL-amyloidosis (AL-A) and light chain deposition disease (LCDD) are individual 
      nosological entities in view of considerable differences in their pathogenesis 
      and pathomorphology. The paper describes a rare case of the concurrence of LCDD 
      and AL-A in a patient with multiple myeloma. Clinically, there was 
      dialysis-dependent renal failure, flail leg syndrome, myocardiopathy, and 
      rhabdomyolysis. At the disease onset, his nephrobiopsy specimen could diagnose 
      LCDD and myeloma or cast nephropathy. The disease was characterized by an 
      aggressive course. Despite the administration of innovative agents, the patient 
      had a short-term remission and died from disease progression. Autopsy 
      additionally revealed amyloid deposition in the heart and kidney. The development 
      of AL-A in the presence of prior LCDD may reflect the progression of the tumor 
      and the appearance of an additional subclone of plasma cells that produce 
      amyloidogenic light chains. The uncommonness of this case is that renal amyloid 
      was found in the tubular casts and absent in the glomeruli, which may be 
      considered as a special form--tubular AL-amyloidosis.
FAU - Rekhtina, I G
AU  - Rekhtina IG
AD  - Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Zakharova, E V
AU  - Zakharova EV
AD  - S.P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow, Russia.
FAU - Stolyarevich, E S
AU  - Stolyarevich ES
AD  - Department of Nephrology, Faculty of Postgraduate Education, A.I. Evdokimov 
      Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, 
      Moscow, Russia.
FAU - Sinitsina, M N
AU  - Sinitsina MN
AD  - Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
FAU - Denisova, E N
AU  - Denisova EN
AD  - Hematology Research Center, Ministry of Health of Russia, Moscow, Russia.
LA  - rus
PT  - Case Reports
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Amyloidosis/*complications/diagnosis
MH  - Fatal Outcome
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Immunoglobulin Light-chain Amyloidosis
MH  - Kidney Diseases/*complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*complications/diagnosis
MH  - Paraproteinemias/*complications/diagnosis/metabolism
EDAT- 2015/08/19 06:00
MHDA- 2015/09/16 06:00
CRDT- 2015/08/19 06:00
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - 10.17116/terarkh201587698-101 [doi]
PST - ppublish
SO  - Ter Arkh. 2015;87(6):98-101. doi: 10.17116/terarkh201587698-101.