PMID- 26281331
OWN - NLM
STAT- MEDLINE
DCOM- 20150910
LR  - 20191113
IS  - 1300-0144 (Print)
IS  - 1300-0144 (Linking)
VI  - 45
IP  - 3
DP  - 2015
TI  - Relationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic 
      hepatitis B patients.
PG  - 634-7
AB  - BACKGROUND/AIM: To determine whether macrophage migration inhibitory factor (MIF) 
      and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis 
      B (HB) are different than in normal individuals and whether the HB surface 
      antigen (HBs Ag) level and viral load are correlated with each other and with the 
      two aforementioned parameters. MATERIALS AND METHODS: Sera were obtained from 52 
      chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and 
      MCP-1 levels were measured. Statistical analyses were performed. A value of P < 
      0.05 was considered statistically significant. RESULTS: The MIF and MCP-1 values 
      of the control group were increased compared to those of the CAHB group. The MIF 
      and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. 
      The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the 
      log10 of the viral loads were positively correlated. CONCLUSION: We conclude that 
      the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may 
      be due to T-cell deficiency, antinuclear antibody seropositivity, and/or 
      inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a 
      greater number of subjects are needed to evaluate the potential role of MIF and 
      MCP in CAHB.
FAU - Gunes, Hayati
AU  - Gunes H
FAU - Mete, Rafet
AU  - Mete R
FAU - Aydin, Murat
AU  - Aydin M
FAU - Topcu, Birol
AU  - Topcu B
FAU - Oran, Mustafa
AU  - Oran M
FAU - Dogan, Mustafa
AU  - Dogan M
FAU - Yildirim, Oguzhan
AU  - Yildirim O
FAU - Erdem, Ilknur
AU  - Erdem I
FAU - Eren Topkaya, Aynur
AU  - Eren Topkaya A
FAU - Gurel, Ahmet
AU  - Gurel A
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
SB  - IM
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hepatitis B Surface Antigens/*blood/genetics
MH  - Hepatitis B, Chronic/*blood/genetics
MH  - Humans
MH  - Macrophage Migration-Inhibitory Factors/*blood/genetics
MH  - Viral Load/genetics
EDAT- 2015/08/19 06:00
MHDA- 2015/09/12 06:00
CRDT- 2015/08/19 06:00
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - 10.3906/sag-1401-171 [doi]
PST - ppublish
SO  - Turk J Med Sci. 2015;45(3):634-7. doi: 10.3906/sag-1401-171.