PMID- 26281716
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20220129
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 79
IP  - 9
DP  - 2016 May 1
TI  - Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models 
      of Schizophrenia.
PG  - 716-726
LID - S0006-3223(15)00577-6 [pii]
LID - 10.1016/j.biopsych.2015.07.005 [doi]
AB  - N-methyl-D-aspartate receptor (NMDAR) hypofunction in parvalbumin-expressing 
      (PV+) inhibitory neurons (INs) may contribute to symptoms in patients with 
      schizophrenia (SZ). This hypothesis was inspired by studies in humans involving 
      NMDAR antagonists that trigger SZ symptoms. Animal models of SZ using 
      neuropharmacology and genetic knockouts have successfully replicated some of the 
      key observations in human subjects involving alteration of gamma band 
      oscillations (GBO) observed in electroencephalography and magnetoencephalography 
      signals. However, it remains to be seen if NMDAR hypofunction in PV+ neurons is 
      fundamental to the phenotype observed in these models. In this review, we discuss 
      some of the key computational models of GBO and their predictions in the context 
      of NMDAR hypofunction in INs. While PV+ INs have been the main focus of SZ 
      studies in animal models, we also discuss the implications of NMDAR hypofunction 
      in other types of INs using computational models for GBO modulation in the visual 
      cortex.
CI  - Copyright (c) 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Jadi, Monika P
AU  - Jadi MP
AD  - Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La 
      Jolla, California; Division of Biological Sciences, University of California at 
      San Diego, La Jolla, California. Electronic address: jadi@salk.edu.
FAU - Behrens, M Margarita
AU  - Behrens MM
AD  - Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La 
      Jolla, California.
FAU - Sejnowski, Terrence J
AU  - Sejnowski TJ
AD  - Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La 
      Jolla, California; Division of Biological Sciences, University of California at 
      San Diego, La Jolla, California.
LA  - eng
GR  - K99 EY025026/EY/NEI NIH HHS/United States
GR  - MH091407/MH/NIMH NIH HHS/United States
GR  - R01 MH091407/MH/NIMH NIH HHS/United States
GR  - T32 MH020002/MH/NIMH NIH HHS/United States
GR  - R01 MH094670/MH/NIMH NIH HHS/United States
GR  - T32MH020002/MH/NIMH NIH HHS/United States
GR  - MH094670/MH/NIMH NIH HHS/United States
GR  - HHMI_/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150717
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Parvalbumins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Cerebral Cortex/*physiopathology
MH  - Electroencephalography
MH  - GABAergic Neurons/metabolism/physiology
MH  - *Gamma Rhythm
MH  - Humans
MH  - Interneurons/metabolism/*physiology
MH  - *Models, Neurological
MH  - Parvalbumins/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/genetics/*physiology
MH  - Schizophrenia/*physiopathology
MH  - gamma-Aminobutyric Acid/physiology
PMC - PMC4720598
MID - NIHMS716171
OTO - NOTNLM
OT  - Computational models
OT  - Gamma oscillations
OT  - Inhibition
OT  - NMDA hypofunction
OT  - Parvalbumin
OT  - Schizophrenia
EDAT- 2015/08/19 06:00
MHDA- 2016/12/31 06:00
PMCR- 2017/05/01
CRDT- 2015/08/19 06:00
PHST- 2014/12/10 00:00 [received]
PHST- 2015/06/03 00:00 [revised]
PHST- 2015/07/07 00:00 [accepted]
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - S0006-3223(15)00577-6 [pii]
AID - 10.1016/j.biopsych.2015.07.005 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2016 May 1;79(9):716-726. doi: 10.1016/j.biopsych.2015.07.005. 
      Epub 2015 Jul 17.