PMID- 26282428
OWN - NLM
STAT- MEDLINE
DCOM- 20160804
LR  - 20181202
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Print)
IS  - 0066-4804 (Linking)
VI  - 59
IP  - 11
DP  - 2015 Nov
TI  - Multicenter study of epidemiological cutoff values and detection of resistance in 
      Candida spp. to anidulafungin, caspofungin, and micafungin using the Sensititre 
      YeastOne colorimetric method.
PG  - 6725-32
LID - 10.1128/AAC.01250-15 [doi]
AB  - Neither breakpoints (BPs) nor epidemiological cutoff values (ECVs) have been 
      established for Candida spp. with anidulafungin, caspofungin, and micafungin when 
      using the Sensititre YeastOne (SYO) broth dilution colorimetric method. In 
      addition, reference caspofungin MICs have so far proven to be unreliable. Candida 
      species wild-type (WT) MIC distributions (for microorganisms in a species/drug 
      combination with no detectable phenotypic resistance) were established for 6,007 
      Candida albicans, 186 C. dubliniensis, 3,188 C. glabrata complex, 119 C. 
      guilliermondii, 493 C. krusei, 205 C. lusitaniae, 3,136 C. parapsilosis complex, 
      and 1,016 C. tropicalis isolates. SYO MIC data gathered from 38 laboratories in 
      Australia, Canada, Europe, Mexico, New Zealand, South Africa, and the United 
      States were pooled to statistically define SYO ECVs. ECVs for anidulafungin, 
      caspofungin, and micafungin encompassing >/=97.5% of the statistically modeled 
      population were, respectively, 0.12, 0.25, and 0.06 mug/ml for C. albicans, 0.12, 
      0.25, and 0.03 mug/ml for C. glabrata complex, 4, 2, and 4 mug/ml for C. 
      parapsilosis complex, 0.5, 0.25, and 0.06 mug/ml for C. tropicalis, 0.25, 1, and 
      0.25 mug/ml for C. krusei, 0.25, 1, and 0.12 mug/ml for C. lusitaniae, 4, 2, and 2 
      mug/ml for C. guilliermondii, and 0.25, 0.25, and 0.12 mug/ml for C. dubliniensis. 
      Species-specific SYO ECVs for anidulafungin, caspofungin, and micafungin 
      correctly classified 72 (88.9%), 74 (91.4%), 76 (93.8%), respectively, of 81 
      Candida isolates with identified fks mutations. SYO ECVs may aid in detecting 
      non-WT isolates with reduced susceptibility to anidulafungin, micafungin, and 
      especially caspofungin, since testing the susceptibilities of Candida spp. to 
      caspofungin by reference methodologies is not recommended.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Espinel-Ingroff, A
AU  - Espinel-Ingroff A
AD  - VCU Medical Center, Richmond, Virginia, USA avingrof@vcu.edu.
FAU - Alvarez-Fernandez, M
AU  - Alvarez-Fernandez M
AD  - Servicio de Microbiologia, Hospital Universitario Central de Asturias, Oviedo, 
      Spain.
FAU - Canton, E
AU  - Canton E
AD  - Unidad de Microbiologia del Centro de Investigacion, Valencia, Spain.
FAU - Carver, P L
AU  - Carver PL
AD  - Department of Clinical, Social and Administrative Sciences, University of 
      Michigan College of Pharmacy, and University of Michigan Health System, Ann 
      Arbor, Michigan, USA.
FAU - Chen, S C-A
AU  - Chen SC
AD  - Centre for Infectious Diseases and Microbiology Laboratory Services, Institute 
      for Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, 
      Australia.
FAU - Eschenauer, G
AU  - Eschenauer G
AD  - Department of Clinical, Social and Administrative Sciences, University of 
      Michigan College of Pharmacy, and University of Michigan Health System, Ann 
      Arbor, Michigan, USA University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania, USA.
FAU - Getsinger, D L
AU  - Getsinger DL
AD  - Stanford University Medical Center, Hospital and Clinics, Palo Alto, California, 
      USA.
FAU - Gonzalez, G M
AU  - Gonzalez GM
AD  - Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico.
FAU - Govender, N P
AU  - Govender NP
AUID- ORCID: 0000-0001-7869-9462
AD  - National Institute for Communicable Diseases and University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Grancini, A
AU  - Grancini A
AD  - Microbiology Lab, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Hanson, K E
AU  - Hanson KE
AD  - Department of Pathology, The University of Utah, Salt Lake City, Utah, USA.
FAU - Kidd, S E
AU  - Kidd SE
AD  - National Mycology Reference Centre, SA Pathology, Adelaide, Australia.
FAU - Klinker, K
AU  - Klinker K
AD  - Department of Pharmacy, UF Health Shands Hospital, Gainesville, Florida, USA.
FAU - Kubin, C J
AU  - Kubin CJ
AD  - Department of Pharmacy, New York Presbyterian Hospital, New York, New York, USA.
FAU - Kus, J V
AU  - Kus JV
AD  - Public Health Ontario, Toronto, Canada.
FAU - Lockhart, S R
AU  - Lockhart SR
AD  - Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, 
      Georgia, USA.
FAU - Meletiadis, J
AU  - Meletiadis J
AD  - University of Athens, Athens, Greece.
FAU - Morris, A J
AU  - Morris AJ
AD  - Clinical Microbiology Laboratory, Auckland City Hospital, Auckland, New Zealand.
FAU - Pelaez, T
AU  - Pelaez T
AD  - Hospital General Universitario Gregorio Maranon, Facultad de Medicina-Universidad 
      Complutense, Madrid, Spain.
FAU - Quindos, G
AU  - Quindos G
AUID- ORCID: 0000-0003-0438-2248
AD  - UFI 11/25, Universidad del Pais Vasco-Euskal Herriko Unibertsitatea, Bilbao, 
      Spain.
FAU - Rodriguez-Iglesias, M
AU  - Rodriguez-Iglesias M
AD  - Hospital Universitario Puerta del Mar, Cadiz, Spain.
FAU - Sanchez-Reus, F
AU  - Sanchez-Reus F
AD  - Servei de Microbiologia Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
FAU - Shoham, S
AU  - Shoham S
AD  - Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
FAU - Wengenack, N L
AU  - Wengenack NL
AD  - Division of Clinical Microbiology, Department of Laboratory Medicine and 
      Pathology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Borrell Sole, N
AU  - Borrell Sole N
AD  - Hospital Universitario Son Dureta, Palma de Mallorca, Spain.
FAU - Echeverria, J
AU  - Echeverria J
AD  - Hospital Donostia, San Sebastian, Spain.
FAU - Esperalba, J
AU  - Esperalba J
AD  - Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
FAU - Gomez-G de la Pedrosa, E
AU  - Gomez-G de la Pedrosa E
AD  - Hospital Universitario Ramon y Cajal, Madrid, Spain.
FAU - Garcia Garcia, I
AU  - Garcia Garcia I
AD  - Hospital Universitario de Salamanca, Salamanca, Spain.
FAU - Linares, M J
AU  - Linares MJ
AD  - Facultad de Medicina, Universidad de Cordoba, Hospital General Universitario 
      Reina Sofia, Cordoba, Spain.
FAU - Marco, F
AU  - Marco F
AD  - Department of Microbiology, ISGlobal, Barcelona Centre for International Health 
      Research, Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.
FAU - Merino, P
AU  - Merino P
AD  - Hospital Clinico Universitario de San Carlos, Madrid, Spain.
FAU - Peman, J
AU  - Peman J
AD  - Hospital Universitario La Fe, Valencia, Spain.
FAU - Perez Del Molino, L
AU  - Perez Del Molino L
AD  - Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
FAU - Rosello Mayans, E
AU  - Rosello Mayans E
AD  - Hospital Universitario Valle Hebron, Barcelona, Spain.
FAU - Rubio Calvo, C
AU  - Rubio Calvo C
AD  - Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
FAU - Ruiz Perez de Pipaon, M
AU  - Ruiz Perez de Pipaon M
AD  - Hospital Universitario Virgen del Rocio, Seville, Spain.
FAU - Yague, G
AU  - Yague G
AD  - Hospital Universitario Virgen De La Arrixaca, Murcia, Spain.
FAU - Garcia-Effron, G
AU  - Garcia-Effron G
AD  - Mycology and Molecular Diagnosis Laboratory, Universidad Nacional del 
      Litoral-CONICET, Santa Fe, Argentina.
FAU - Guinea, J
AU  - Guinea J
AUID- ORCID: 0000-0002-7901-8355
AD  - Hospital General Universitario Gregorio Maranon, Facultad de Medicina-Universidad 
      Complutense, Madrid, Spain.
FAU - Perlin, D S
AU  - Perlin DS
AD  - Public Health Research Institute, New Jersey Medical School-Rutgers, Newark, New 
      Jersey, USA.
FAU - Sanguinetti, M
AU  - Sanguinetti M
AD  - Institute of Microbiology and Institute of Hygiene d'Universita Cattolica del 
      Sacro Cuore, Rome, Italy.
FAU - Shields, R
AU  - Shields R
AD  - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
FAU - Turnidge, J
AU  - Turnidge J
AD  - University of Adelaide, Adelaide, Australia.
LA  - eng
GR  - K08 AI114883/AI/NIAID NIH HHS/United States
GR  - R01 AI109025/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20150817
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Antifungal Agents)
RN  - 0 (Echinocandins)
RN  - 0 (Lipopeptides)
RN  - 9HLM53094I (Anidulafungin)
RN  - F0XDI6ZL63 (Caspofungin)
RN  - R10H71BSWG (Micafungin)
SB  - IM
MH  - Anidulafungin
MH  - Antifungal Agents/*pharmacology
MH  - Candida/*drug effects/genetics
MH  - Caspofungin
MH  - Echinocandins/*pharmacology
MH  - Lipopeptides/*pharmacology
MH  - Micafungin
MH  - Microbial Sensitivity Tests
MH  - Mutation/genetics
PMC - PMC4604361
EDAT- 2015/08/19 06:00
MHDA- 2016/08/05 06:00
PMCR- 2016/05/01
CRDT- 2015/08/19 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/08/01 00:00 [accepted]
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/08/05 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - AAC.01250-15 [pii]
AID - 01250-15 [pii]
AID - 10.1128/AAC.01250-15 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 2015 Nov;59(11):6725-32. doi: 10.1128/AAC.01250-15. 
      Epub 2015 Aug 17.