PMID- 26282450 OWN - NLM STAT- MEDLINE DCOM- 20151231 LR - 20181202 IS - 1528-1167 (Electronic) IS - 0013-9580 (Linking) VI - 56 IP - 10 DP - 2015 Oct TI - The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population. PG - e161-7 LID - 10.1111/epi.13087 [doi] AB - The use of lamotrigine (LTG) can be limited by the occurrence of cutaneous adverse drug reactions (cADRs) that range from maculopapular eruption (MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen (HLA)-related genetic risk factors for carbamazepine-induced cADR have been identified. However, the HLA-related genetic risk factors associated with LTG-induced cADR are not yet well known. We performed HLA genotyping in 50 Korean patients with epilepsy, including 21 patients presenting LTG-induced MPE and 29 LTG-tolerant patients. A significant association between the HLA-A*2402 allele and LTG-induced MPE was identified, in comparison with the LTG-tolerant group (odds ratio [OR] 4.09, p = 0.025) and the general Korean population (OR 3.949, p = 0.005). The frequencies of the Cw*0102 or Cw*0702 alleles were significantly higher in the LTG-MPE group than in the Korean population, whereas the frequency of the A*3303 allele was lower. The coexistence of the A*2402 and Cw*0102 alleles was significantly associated with the LTG-MPE group when compared to the LTG-tolerant group (OR 7.88, p = 0.007). In addition, the Cw*0701 allele was more frequent in the LTG-tolerant group than in the Korean population. These findings suggest the presence of HLA-related genetic risk factors for LTG-induced MPE in the Korean population. CI - Wiley Periodicals, Inc. (c) 2015 International League Against Epilepsy. FAU - Moon, Jangsup AU - Moon J AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Park, Han-Ki AU - Park HK AD - Department of Internal Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. FAU - Chu, Kon AU - Chu K AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Sunwoo, Jun-Sang AU - Sunwoo JS AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Byun, Jung-Ick AU - Byun JI AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Lim, Jung-Ah AU - Lim JA AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Kim, Tae-Joon AU - Kim TJ AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Shin, Jung-Won AU - Shin JW AD - Department of Neurology, CHA Bundang Medical Center, CHA University, Seoungnam, Korea. FAU - Lee, Soon-Tae AU - Lee ST AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Jung, Keun-Hwa AU - Jung KH AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Jung, Ki-Young AU - Jung KY AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Jeon, Daejong AU - Jeon D AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. FAU - Kim, Dong Wook AU - Kim DW AD - Department of Neurology, Konkuk University College of Medicine, Seoul, Korea. FAU - Yu, Kyung-Sang AU - Yu KS AD - Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea. FAU - Jang, In-Jin AU - Jang IJ AD - Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea. FAU - Kang, Hye-Ryun AU - Kang HR AD - Department of Internal Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. FAU - Park, Heung-Woo AU - Park HW AD - Department of Internal Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. FAU - Lee, Sang Kun AU - Lee SK AD - Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. AD - Program in Neuroscience, Seoul National University College of Medicine, Seoul, Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150817 PL - United States TA - Epilepsia JT - Epilepsia JID - 2983306R RN - 0 (Anticonvulsants) RN - 0 (HLA-A*24:02 antigen) RN - 0 (HLA-A24 Antigen) RN - 0 (Triazines) RN - U3H27498KS (Lamotrigine) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Anticonvulsants/*adverse effects MH - Drug Eruptions/*etiology/*genetics MH - Epilepsy/drug therapy MH - Female MH - Gene Frequency MH - Genotype MH - HLA-A24 Antigen/*genetics MH - Humans MH - Lamotrigine MH - Male MH - Middle Aged MH - Republic of Korea MH - Triazines/*adverse effects MH - Young Adult OTO - NOTNLM OT - Cutaneous adverse reaction OT - HLA OT - Lamotrigine OT - Maculopapular eruption OT - Rash EDAT- 2015/08/19 06:00 MHDA- 2016/01/01 06:00 CRDT- 2015/08/19 06:00 PHST- 2015/06/19 00:00 [accepted] PHST- 2015/08/19 06:00 [entrez] PHST- 2015/08/19 06:00 [pubmed] PHST- 2016/01/01 06:00 [medline] AID - 10.1111/epi.13087 [doi] PST - ppublish SO - Epilepsia. 2015 Oct;56(10):e161-7. doi: 10.1111/epi.13087. Epub 2015 Aug 17.