PMID- 26282452
OWN - NLM
STAT- MEDLINE
DCOM- 20160729
LR  - 20151012
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 201
DP  - 2015 Dec 15
TI  - Carbon monoxide and stroke: A time series study of ambient air pollution and 
      emergency hospitalizations.
PG  - 4-9
LID - S0167-5273(15)30221-7 [pii]
LID - 10.1016/j.ijcard.2015.07.099 [doi]
AB  - BACKGROUND: Recent experimental and clinical studies suggested that exogenous 
      carbon monoxide (CO) at low concentrations may have beneficial neuroprotective 
      effects under certain circumstances. However, population-based epidemiological 
      studies of environmentally relevant CO exposure generated mixed findings. The 
      present study aimed to examine the short-term association of ambient CO with 
      emergency stroke hospitalizations. METHODS: A time series study was conducted. 
      Daily air pollution concentrations and emergency hospital admission data from 
      January 2004 to December 2011 in Hong Kong were collected. Generalized additive 
      Poisson models were used to estimate the associations between daily 24-hour mean 
      concentrations of CO and emergency hospital admissions for stroke, while 
      controlling for other traffic related co-pollutants: NO(2) and PM(2).(5). Sensitivity 
      analyses were performed using daily 1-hour maximum concentration of CO as 
      exposure indicator. RESULTS: Negative associations were observed between ambient 
      CO concentrations and emergency hospital admissions for stroke. The previous 1-3 
      day cumulative exposure to CO was associated with a -2.0% (95%CI, -3.3% to -0.7%) 
      decrease in stroke admissions per interquartile range (IQR) increment in CO 
      concentration (0.3 ppm). Similar results were obtained when using 1-hour maximum 
      concentration of CO as exposure indicator. The negative association was robust to 
      the co-pollutant adjustment for either NO(2) or PM(2).(5). Females and elders appeared 
      to be more sensitive to ambient CO exposure. The negative association tended to 
      be larger in cool season. CONCLUSION: Short-term exposure to ambient CO was 
      associated with decreased risk of emergency hospitalizations for stroke, 
      suggesting some acute protective effects of CO exposure against stroke onsets.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Tian, Linwei
AU  - Tian L
AD  - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong 
      Kong, Hong Kong Special Administrative Region, China. Electronic address: 
      linweit@hku.hk.
FAU - Qiu, Hong
AU  - Qiu H
AD  - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong 
      Kong, Hong Kong Special Administrative Region, China.
FAU - Pun, Vivian C
AU  - Pun VC
AD  - The Jockey Club School of Public Health and Primary Care, The Chinese University 
      of Hong Kong, Hong Kong Special Administrative Region, China.
FAU - Ho, Kin-Fai
AU  - Ho KF
AD  - The Jockey Club School of Public Health and Primary Care, The Chinese University 
      of Hong Kong, Hong Kong Special Administrative Region, China.
FAU - Chan, Chi Sing
AU  - Chan CS
AD  - The Jockey Club School of Public Health and Primary Care, The Chinese University 
      of Hong Kong, Hong Kong Special Administrative Region, China.
FAU - Yu, Ignatius T S
AU  - Yu IT
AD  - The Jockey Club School of Public Health and Primary Care, The Chinese University 
      of Hong Kong, Hong Kong Special Administrative Region, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150801
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Particulate Matter)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Air Pollution/*adverse effects
MH  - Carbon Monoxide/*adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Emergency Medical Services/*trends
MH  - Female
MH  - Hong Kong/epidemiology
MH  - Hospitalization/*trends
MH  - Humans
MH  - Interrupted Time Series Analysis/trends
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Particulate Matter/*adverse effects
MH  - Stroke/diagnosis/*epidemiology
OTO - NOTNLM
OT  - Carbon monoxide
OT  - Emergency hospital admission
OT  - Stroke
OT  - Time series study
EDAT- 2015/08/19 06:00
MHDA- 2016/07/30 06:00
CRDT- 2015/08/19 06:00
PHST- 2015/05/14 00:00 [received]
PHST- 2015/07/06 00:00 [revised]
PHST- 2015/07/29 00:00 [accepted]
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/07/30 06:00 [medline]
AID - S0167-5273(15)30221-7 [pii]
AID - 10.1016/j.ijcard.2015.07.099 [doi]
PST - ppublish
SO  - Int J Cardiol. 2015 Dec 15;201:4-9. doi: 10.1016/j.ijcard.2015.07.099. Epub 2015 
      Aug 1.