PMID- 26283509
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20161230
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 5
IP  - 11
DP  - 2015 Nov
TI  - Pulmonary function in never-smoker patients with chronic rhinosinusitis.
PG  - 990-5
LID - 10.1002/alr.21628 [doi]
AB  - BACKGROUND: A close relationship between upper and lower respiratory tract 
      diseases has been reported. The purpose of this study was to evaluate lung 
      function in patients with chronic rhinosinusitis (CRS) who have never smoked. 
      METHODS: A total of 208 patients with CRS were enrolled in this study. Of these 
      subjects, 96 patients were ever smokers and 112 patients were never smokers. CRS 
      patients with lower pulmonary diseases including chronic obstructive pulmonary 
      disease (COPD) and asthma were excluded from this study. Age-matched normal 
      control subjects (n = 55) who were never smokers were also recruited. Pulmonary 
      function testing was performed using spirometry. Lund-Mackay computed tomography 
      (CT) score, peripheral blood eosinophil count, and immunoglobulin E (IgE) level 
      in serum samples were examined. Nasal obstruction was evaluated by active 
      anterior rhinomanometry. RESULTS: CRS patients who were ever smokers have 
      decreased lung function. Never-smoking patients with CRS also showed significant 
      obstructive lung function changes as compared with normal controls. No 
      significant correlation was detected between the clinical parameters (CT score, 
      eosinophil count, IgE level, and nasal resistance) and lung function. CONCLUSION: 
      Asymptomatic obstructive lung function changes were observed in never-smoking 
      patients with CRS. Our findings suggest that patients with CRS should be followed 
      carefully in order to detect lung diseases.
CI  - (c) 2015 ARS-AAOA, LLC.
FAU - Kariya, Shin
AU  - Kariya S
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Okano, Mitsuhiro
AU  - Okano M
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Higaki, Takaya
AU  - Higaki T
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Noyama, Yasuyuki
AU  - Noyama Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Haruna, Takenori
AU  - Haruna T
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Nishizaki, Kazunori
AU  - Nishizaki K
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150818
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/*diagnosis/physiopathology
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Lung/physiology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Rhinitis/*diagnosis/physiopathology
MH  - Sinusitis/*diagnosis/physiopathology
MH  - Smoking
MH  - Tomography, X-Ray Computed
MH  - Young Adult
OTO - NOTNLM
OT  - asthma
OT  - chronic obstructive pulmonary disease
OT  - cigarette
OT  - lung function
OT  - paranasal sinus
OT  - paranasal sinus diseases
OT  - rhinitis
OT  - sinusitis
OT  - tobacco
EDAT- 2015/08/19 06:00
MHDA- 2016/11/12 06:00
CRDT- 2015/08/19 06:00
PHST- 2015/04/28 00:00 [received]
PHST- 2015/06/26 00:00 [revised]
PHST- 2015/07/20 00:00 [accepted]
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/11/12 06:00 [medline]
AID - 10.1002/alr.21628 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2015 Nov;5(11):990-5. doi: 10.1002/alr.21628. Epub 2015 
      Aug 18.